6PT5

Crystal Structure of Class D Beta-lactamase OXA-48 with Cefoxitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 301

Chain	Residue
A	ARG206
C	ARG206

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site_id	AC2
Number of Residues	11
Details	binding site for residue 1S7 A 302

Chain	Residue
A	TYR211
A	THR213
A	ARG214
A	ARG250
A	SER70
A	TRP105
A	SER118
A	VAL120
A	LEU158
A	THR209
A	GLY210

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL B 301

Chain	Residue
B	ARG206
D	ARG206

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site_id	AC4
Number of Residues	15
Details	binding site for Di-peptide 1S7 B 302 and SER B 70

Chain	Residue
B	PRO68
B	ALA69
B	THR71
B	PHE72
B	LYS73
B	SER118
B	VAL120
B	LEU158
B	LYS208
B	THR209
B	GLY210
B	TYR211
B	THR213
B	ARG214
B	ARG250

---

site_id	AC5
Number of Residues	18
Details	binding site for Di-peptide 1S7 B 302 and ARG B 250

Chain	Residue
B	ALA69
B	SER70
B	SER118
B	VAL120
B	LEU158
B	THR209
B	GLY210
B	TYR211
B	THR213
B	ARG214
B	TRP221
B	MET237
B	LEU247
B	GLY248
B	LEU249
B	GLN251
B	ALA252
B	THR254

---

site_id	AC6
Number of Residues	18
Details	binding site for Di-peptide 1S7 C 301 and ARG C 250

Chain	Residue
C	ALA69
C	SER70
C	SER118
C	VAL120
C	LEU158
C	THR209
C	GLY210
C	TYR211
C	SER212
C	THR213
C	ARG214
C	TRP221
C	LEU247
C	GLY248
C	LEU249
C	GLN251
C	ALA252
C	THR254

---

site_id	AC7
Number of Residues	16
Details	binding site for Di-peptide 1S7 C 301 and SER C 70

Chain	Residue
C	PRO68
C	ALA69
C	THR71
C	PHE72
C	LYS73
C	SER118
C	VAL120
C	LEU158
C	LYS208
C	THR209
C	GLY210
C	TYR211
C	SER212
C	THR213
C	ARG214
C	ARG250

---

site_id	AC8
Number of Residues	15
Details	binding site for Di-peptide 1S7 D 301 and SER D 70

Chain	Residue
D	PRO68
D	ALA69
D	THR71
D	PHE72
D	LYS73
D	SER118
D	VAL120
D	LEU158
D	LYS208
D	THR209
D	GLY210
D	TYR211
D	THR213
D	ARG214
D	ARG250

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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