6PNP

Crystal structure of the splice insert-free neurexin-1 LNS2 domain in complex with neurexophilin-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Neurexin-1	polymer	194	21133.8	1	UniProt (Q9CS84) Pfam (PF02210)	Mus musculus (Mouse)	Neurexin I-alpha,Neurexin-1-alpha
2	B (B)	Neurexophilin-1	polymer	168	19081.4	1	UniProt (Q63366) Pfam (PF06312)	Rattus norvegicus (Rat)	Neurophilin
3	C, D (A, B)	water	water		18.0	67	Chemie (HOH)

Sequence modifications

A: 283 - 480 (UniProt: Q9CS84)

PDB	External Database	Details
Asp 280	-	expression tag
Ala 281	-	expression tag
Ser 282	-	expression tag
Ala 293	Cys 293	engineered mutation
-	His 379	deletion
-	Ser 380	deletion
-	Gly 381	deletion
-	Ile 382	deletion
-	Gly 383	deletion
-	His 384	deletion
-	Ala 385	deletion
-	Met 386	deletion
-	Val 387	deletion
-	Asn 388	deletion
-	Lys 389	deletion
-	Leu 390	deletion
-	His 391	deletion
-	Cys 392	deletion
-	Ser 393	deletion
Ala 481	-	expression tag
Ala 482	-	expression tag
Leu 483	-	expression tag
Glu 484	-	expression tag
Val 485	-	expression tag
Leu 486	-	expression tag
Phe 487	-	expression tag
Gln 488	-	expression tag

B: 119 - 271 (UniProt: Q63366)

PDB	External Database	Details
Asp 110	-	expression tag
Ala 111	-	expression tag
Ala 112	-	expression tag
Gln 113	-	expression tag
Pro 114	-	expression tag
Ala 115	-	expression tag
Ala 116	-	expression tag
Arg 117	-	expression tag
Asp 118	-	expression tag
Asp 146	Asn 146	engineered mutation
Asp 156	Asn 156	engineered mutation
Asp 162	Asn 162	engineered mutation
Leu 272	-	expression tag
Glu 273	-	expression tag
Val 274	-	expression tag
Leu 275	-	expression tag
Phe 276	-	expression tag
Gln 277	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40215.2
All*	Total formula weight	40215.2

*Water molecules are not included.