6PM9
Crystal structure of the core catalytic domain of human O-GlcNAcase bound to MK-8719
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | O-GlcNAcase TIM-barrel domain | polymer | 388 | 43642.1 | 4 | UniProt (O60502) Pfam (PF07555) In PDB | Homo sapiens (Human) | OGA,Beta-N-acetylglucosaminidase,Beta-N-acetylhexosaminidase,Beta-hexosaminidase,Meningioma-expressed antigen 5,N-acetyl-beta-D-glucosaminidase,N-acetyl-beta-glucosaminidase,Nuclear cytoplasmic O-GlcNAcase and acetyltransferase,NCOAT |
2 | E, F, G, H | O-GlcNAcase stalk domain | polymer | 161 | 18762.5 | 4 | UniProt (O60502) In PDB | Homo sapiens (Human) | OGA,Beta-N-acetylglucosaminidase,Beta-N-acetylhexosaminidase,Beta-hexosaminidase,Meningioma-expressed antigen 5,N-acetyl-beta-D-glucosaminidase,N-acetyl-beta-glucosaminidase,Nuclear cytoplasmic O-GlcNAcase and acetyltransferase,NCOAT |
3 | A, B, C, D | (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | non-polymer | 268.3 | 4 | Chemie (OQ1) | |||
4 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 14 - 400 (UniProt: O60502)
E, F, G, H: 554 - 705 (UniProt: O60502)
PDB | External Database | Details |
---|---|---|
Gly 13 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 553 | - | initiating methionine |
His 706 | - | expression tag |
His 707 | - | expression tag |
His 708 | - | expression tag |
His 709 | - | expression tag |
His 710 | - | expression tag |
His 711 | - | expression tag |
His 712 | - | expression tag |
His 713 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 249618.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1073.1 | |
All* | Total formula weight | 250691.4 |