6PK0

Crystal Structure of OXA-48 with Hydrolyzed Imipenem

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	OXA family beta-lactamase	polymer	263	30869.9	4	UniProt (A0A482LRD5) Pfam (PF00905) UniProt (by SIFTS) (Q6XEC0)	Klebsiella pneumoniae
2	E, F, J, N, Q (A, B, C, D)	(2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid	non-polymer		317.4	5	Chemie (HIW)
3	G, O (A, C)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	H, I, K, L, M... (A, B, C)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	R, S, T, U (A, B, C, D)	water	water		18.0	826	Chemie (HOH)

Sequence modifications

A, B, C, D: 25 - 265 (UniProt: A0A482LRD5)

PDB	External Database	Details
Met 3	-	initiating methionine
Lys 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Met 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
Glu 18	-	expression tag
Asn 19	-	expression tag
Leu 20	-	expression tag
Tyr 21	-	expression tag
Phe 22	-	expression tag
Gln 23	-	expression tag
Gly 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123479.5
Non-Polymers*	Number of molecules	13
	Total formula weight	2210.3
All*	Total formula weight	125689.8

*Water molecules are not included.