6PK0

Crystal Structure of OXA-48 with Hydrolyzed Imipenem

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue HIW A 301

Chain	Residue
A	ALA69
A	GLY210
A	TYR211
A	SER244
A	ARG250
A	HOH402
A	SER70
A	KCX73
A	ILE102
A	TRP105
A	SER118
A	VAL120
A	LEU158
A	THR209

---

site_id	AC2
Number of Residues	7
Details	binding site for residue HIW A 302

Chain	Residue
A	SER184
A	GLU185
A	ARG186
A	HOH464
C	ASP82
C	HIS140
C	HIS182

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 303

Chain	Residue
A	ARG206
A	HOH572
B	ARG206

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 304

Chain	Residue
A	LYS94
A	TRP95
A	ASP96
A	PRO121
A	HOH449
A	HOH461
A	HOH486
A	HOH519

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 305

Chain	Residue
A	PHE22
A	TRP25
A	TRP47
A	THR167
A	ILE170
A	SER171
A	ARG174

---

site_id	AC6
Number of Residues	14
Details	binding site for residue HIW B 301

Chain	Residue
B	ALA69
B	SER70
B	KCX73
B	TRP105
B	TYR117
B	SER118
B	VAL120
B	LEU158
B	THR209
B	GLY210
B	TYR211
B	ARG250
B	HOH443
B	HOH575

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL B 302

Chain	Residue
B	ARG100
B	ASP101
B	ILE102
B	HOH557

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL B 303

Chain	Residue
B	TRP25
B	THR167
B	SER171
B	ARG174
B	HOH545

---

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL B 304

Chain	Residue
A	VAL92
A	ASP108
A	THR113
B	ASP229

---

site_id	AD1
Number of Residues	16
Details	binding site for residue HIW C 301

Chain	Residue
C	ALA69
C	SER70
C	KCX73
C	ILE102
C	THR104
C	TYR117
C	SER118
C	VAL120
C	LEU158
C	THR209
C	GLY210
C	TYR211
C	ARG250
C	HOH470
C	HOH505
C	HOH507

---

site_id	AD2
Number of Residues	2
Details	binding site for residue CL C 302

Chain	Residue
C	ARG206
D	ARG206

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL C 303

Chain	Residue
C	LYS94
C	TRP95
C	ASP96
C	PRO121
C	HOH436
C	HOH448
C	HOH534

---

site_id	AD4
Number of Residues	12
Details	binding site for residue HIW D 301

Chain	Residue
D	GLY210
D	TYR211
D	ARG250
D	HOH407
D	ALA69
D	SER70
D	KCX73
D	SER118
D	VAL120
D	LEU158
D	LYS208
D	THR209

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---