6PHC

Pfs25 in complex with the human transmission blocking antibody 2544

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (I, E)	25 kDa ookinete surface antigen	polymer	184	20233.3	2	UniProt (P13829) Pfam (PF06247)	Plasmodium falciparum	Pfs25
2	B, E (A, C)	2544 Antibody Fab, Heavy Chain	polymer	228	24460.2	2		Homo sapiens (Human)
3	C, F (B, D)	2544 Antibody Fab, Light Chain	polymer	217	23834.6	2		Homo sapiens (Human)
4	G, H, I, J (I, C)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)

Sequence modifications

I, E: 1 - 171 (UniProt: P13829)

PDB	External Database	Details
Glu -2	-	expression tag
Thr -1	-	expression tag
Gly 0	-	expression tag
Gln 91	Asn 112	conflict
Gln 144	Asn 165	conflict
Gln 164	Asn 187	conflict
Gly 172	-	expression tag
Thr 173	-	expression tag
Lys 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	137056.1
Non-Polymers*	Number of molecules	4
	Total formula weight	368.4
All*	Total formula weight	137424.5

*Water molecules are not included.