6PFO

Crystal structure of N-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Maltodextrin-binding protein,Calcitonin receptor	polymer	484	54323.2	2	UniProt (A0A0A8UN35) UniProt (P30988) Pfam (PF02793)	Escherichia coli	CT-R
2	C, D (C, D)	Calcitonin	polymer	18	1872.1	2	UniProt (Q92163) Pfam (PF00214)	Oncorhynchus sp.
3	E, F (E, F)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
4	G, H, J, K (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	I (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	L, M, N, O (A, B, C, D)	water	water		18.0	652	Chemie (HOH)

Sequence modifications

A, B: -335 - 31 (UniProt: A0A0A8UN35)

PDB	External Database	Details
Met -336	-	initiating methionine
Asn 32	-	linker
Ala 33	-	linker
Ala 34	-	linker
Ala 35	-	linker
Glu 36	-	linker
Phe 37	-	linker

A, B: 38 - 141 (UniProt: P30988)

PDB	External Database	Details
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag

C, D: 16 - 32 (UniProt: Q92163)

PDB	External Database	Details
Nh2 33	-	amidation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112390.6
Branched	Number of molecules	2
	Total formula weight	684.6
Non-Polymers*	Number of molecules	5
	Total formula weight	980.9
All*	Total formula weight	114056.1

*Water molecules are not included.