6PEQ
GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, G, H (A, B, C, D) | Glutamate receptor 2 | polymer | 889 | 99530.4 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | C, D, E, F (E, F, G, H) | Protein cornichon homolog 3 | polymer | 174 | 20262.8 | 4 | UniProt (Q6ZWS4) Pfam (PF03311) | Mus musculus (Mouse) | CNIH-3,Cornichon family AMPA receptor auxiliary protein 3 |
| 3 | FA, I, N, Z (D, A, B, C) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) | |||
| 4 | AA, BA, GA, HA, IA... (C, D, A, B) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 8 | Chemie (OLC) | |||
| 5 | CA, DA, EA, JA, K... (C, D, A, B, F...) | PALMITOLEIC ACID | non-polymer | 254.4 | 14 | Chemie (PAM) | |||
| 6 | T, U, W, X (E, F, G, H) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) |
Sequence modifications
A, B, C, D: -20 - 847 (UniProt: P19491)
E, F, G, H: 1 - 160 (UniProt: Q6ZWS4)
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | conflict |
| Asp 848 | - | expression tag |
| Tyr 849 | - | expression tag |
| Lys 850 | - | expression tag |
| Asp 851 | - | expression tag |
| Asp 852 | - | expression tag |
| Asp 853 | - | expression tag |
| Asp 854 | - | expression tag |
| Lys 855 | - | expression tag |
| Glu 856 | - | expression tag |
| Gly 857 | - | expression tag |
| Tyr 858 | - | expression tag |
| Asn 859 | - | expression tag |
| Val 860 | - | expression tag |
| Tyr 861 | - | expression tag |
| Gly 862 | - | expression tag |
| Ile 863 | - | expression tag |
| Glu 864 | - | expression tag |
| Ser 865 | - | expression tag |
| Val 866 | - | expression tag |
| Lys 867 | - | expression tag |
| Ile 868 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Arg 163 | - | expression tag |
| Gly 164 | - | expression tag |
| Gly 165 | - | expression tag |
| Thr 166 | - | expression tag |
| Glu 167 | - | expression tag |
| Thr 168 | - | expression tag |
| Ser 169 | - | expression tag |
| Gln 170 | - | expression tag |
| Val 171 | - | expression tag |
| Ala 172 | - | expression tag |
| Pro 173 | - | expression tag |
| Ala 174 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 479172.6 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 9597.7 | |
| All* | Total formula weight | 488770.3 |
