6PEQ
GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, G, H (A, B, C, D) | Glutamate receptor 2 | polymer | 889 | 99530.4 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | C, D, E, F (E, F, G, H) | Protein cornichon homolog 3 | polymer | 174 | 20262.8 | 4 | UniProt (Q6ZWS4) Pfam (PF03311) | Mus musculus (Mouse) | CNIH-3,Cornichon family AMPA receptor auxiliary protein 3 |
| 3 | FA, I, N, Z (D, A, B, C) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) PubChem (208953) | |||
| 4 | AA, BA, GA, HA, IA... (C, D, A, B) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 8 | Chemie (OLC) PubChem (25021708) PubChem (46840179) PubChem (54294271) PubChem (54294270) PubChem (5283468) PubChem (5364833) PubChem (33022) PubChem (11451146) PubChem (12178130) | |||
| 5 | CA, DA, EA, JA, K... (C, D, A, B, F...) | PALMITOLEIC ACID | non-polymer | 254.4 | 14 | Chemie (PAM) PubChem (445638) PubChem (5282745) PubChem (4668) | |||
| 6 | T, U, W, X (E, F, G, H) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) |
Sequence modifications
A, B, C, D: -20 - 847 (UniProt: P19491)
E, F, G, H: 1 - 160 (UniProt: Q6ZWS4)
| PDB | External Database | Details |
|---|---|---|
| Arg 586 | Gln 607 | conflict |
| Asp 848 | - | expression tag |
| Tyr 849 | - | expression tag |
| Lys 850 | - | expression tag |
| Asp 851 | - | expression tag |
| Asp 852 | - | expression tag |
| Asp 853 | - | expression tag |
| Asp 854 | - | expression tag |
| Lys 855 | - | expression tag |
| Glu 856 | - | expression tag |
| Gly 857 | - | expression tag |
| Tyr 858 | - | expression tag |
| Asn 859 | - | expression tag |
| Val 860 | - | expression tag |
| Tyr 861 | - | expression tag |
| Gly 862 | - | expression tag |
| Ile 863 | - | expression tag |
| Glu 864 | - | expression tag |
| Ser 865 | - | expression tag |
| Val 866 | - | expression tag |
| Lys 867 | - | expression tag |
| Ile 868 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Arg 163 | - | expression tag |
| Gly 164 | - | expression tag |
| Gly 165 | - | expression tag |
| Thr 166 | - | expression tag |
| Glu 167 | - | expression tag |
| Thr 168 | - | expression tag |
| Ser 169 | - | expression tag |
| Gln 170 | - | expression tag |
| Val 171 | - | expression tag |
| Ala 172 | - | expression tag |
| Pro 173 | - | expression tag |
| Ala 174 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 479172.6 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 9597.7 | |
| All* | Total formula weight | 488770.3 |
