6PEQ

GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity
E	0005102	molecular_function	signaling receptor binding
E	0016192	biological_process	vesicle-mediated transport
E	0016247	molecular_function	channel regulator activity
E	0030425	cellular_component	dendrite
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0035249	biological_process	synaptic transmission, glutamatergic
E	0042391	biological_process	regulation of membrane potential
E	0043198	cellular_component	dendritic shaft
E	0045202	cellular_component	synapse
E	0045211	cellular_component	postsynaptic membrane
E	0051668	biological_process	localization within membrane
E	0098978	cellular_component	glutamatergic synapse
E	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
E	2000311	biological_process	regulation of AMPA receptor activity
F	0005102	molecular_function	signaling receptor binding
F	0016192	biological_process	vesicle-mediated transport
F	0016247	molecular_function	channel regulator activity
F	0030425	cellular_component	dendrite
F	0032281	cellular_component	AMPA glutamate receptor complex
F	0035249	biological_process	synaptic transmission, glutamatergic
F	0042391	biological_process	regulation of membrane potential
F	0043198	cellular_component	dendritic shaft
F	0045202	cellular_component	synapse
F	0045211	cellular_component	postsynaptic membrane
F	0051668	biological_process	localization within membrane
F	0098978	cellular_component	glutamatergic synapse
F	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
F	2000311	biological_process	regulation of AMPA receptor activity
G	0005102	molecular_function	signaling receptor binding
G	0016192	biological_process	vesicle-mediated transport
G	0016247	molecular_function	channel regulator activity
G	0030425	cellular_component	dendrite
G	0032281	cellular_component	AMPA glutamate receptor complex
G	0035249	biological_process	synaptic transmission, glutamatergic
G	0042391	biological_process	regulation of membrane potential
G	0043198	cellular_component	dendritic shaft
G	0045202	cellular_component	synapse
G	0045211	cellular_component	postsynaptic membrane
G	0051668	biological_process	localization within membrane
G	0098978	cellular_component	glutamatergic synapse
G	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
G	2000311	biological_process	regulation of AMPA receptor activity
H	0005102	molecular_function	signaling receptor binding
H	0016192	biological_process	vesicle-mediated transport
H	0016247	molecular_function	channel regulator activity
H	0030425	cellular_component	dendrite
H	0032281	cellular_component	AMPA glutamate receptor complex
H	0035249	biological_process	synaptic transmission, glutamatergic
H	0042391	biological_process	regulation of membrane potential
H	0043198	cellular_component	dendritic shaft
H	0045202	cellular_component	synapse
H	0045211	cellular_component	postsynaptic membrane
H	0051668	biological_process	localization within membrane
H	0098978	cellular_component	glutamatergic synapse
H	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
H	2000311	biological_process	regulation of AMPA receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue ZK1 A 901

Chain	Residue
A	TYR405
A	TYR450
A	PRO478
A	LEU479
A	THR480
A	ARG485
A	GLY653
A	SER654
A	TYR732

---

site_id	AC2
Number of Residues	4
Details	binding site for residue OLC A 902

Chain	Residue
A	TYR523
A	MET527
A	PAM903
A	PAM904

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PAM A 903

Chain	Residue
A	TYR523
A	MET527
A	VAL530
A	OLC902
D	OLC903

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PAM A 904

Chain	Residue
A	TYR523
A	OLC902
A	PAM905

---

site_id	AC5
Number of Residues	1
Details	binding site for residue PAM A 905

Chain	Residue
A	PAM904

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ZK1 B 901

Chain	Residue
B	TYR405
B	TYR450
B	PRO478
B	LEU479
B	THR480
B	ARG485
B	GLY653
B	SER654
B	THR686
B	TYR732

---

site_id	AC7
Number of Residues	2
Details	binding site for residue OLC B 902

Chain	Residue
B	MET527
B	PAM904

---

site_id	AC8
Number of Residues	4
Details	binding site for residue OLC B 903

Chain	Residue
A	ILE600
B	SER537
B	PAM904
G	LEU69

---

site_id	AC9
Number of Residues	6
Details	binding site for residue PAM B 904

Chain	Residue
B	TYR523
B	MET527
B	ILE798
B	OLC902
B	OLC903
B	PAM905

---

site_id	AD1
Number of Residues	4
Details	binding site for residue PAM B 905

Chain	Residue
B	PHE515
B	ILE798
B	PAM904
B	PAM906

---

site_id	AD2
Number of Residues	2
Details	binding site for residue PAM B 906

Chain	Residue
B	PAM905
F	CLR201

---

site_id	AD3
Number of Residues	4
Details	binding site for residue CLR E 201

Chain	Residue
A	TYR797
E	MET11
E	ALA18
E	LEU157

---

site_id	AD4
Number of Residues	6
Details	binding site for residue CLR F 201

Chain	Residue
B	TYR797
B	PAM906
F	LEU14
F	ALA18
F	MET153
F	LEU157

---

site_id	AD5
Number of Residues	1
Details	binding site for residue PAM F 202

Chain	Residue
F	GLN86

---

site_id	AD6
Number of Residues	5
Details	binding site for residue CLR G 201

Chain	Residue
C	TYR797
C	PAM906
G	MET11
G	ALA18
G	LEU157

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CLR H 201

Chain	Residue
D	TYR797
D	PAM907
H	ALA18
H	LEU157

---

site_id	AD8
Number of Residues	2
Details	binding site for residue PAM H 202

Chain	Residue
H	ILE80
H	GLN86

---

site_id	AD9
Number of Residues	9
Details	binding site for residue ZK1 C 901

Chain	Residue
C	TYR405
C	TYR450
C	PRO478
C	LEU479
C	THR480
C	ARG485
C	GLY653
C	SER654
C	TYR732

---

site_id	AE1
Number of Residues	2
Details	binding site for residue OLC C 902

Chain	Residue
C	TYR523
C	PAM905

---

site_id	AE2
Number of Residues	5
Details	binding site for residue OLC C 903

Chain	Residue
B	SER595
B	ILE600
C	SER537
C	VAL538
C	PAM904

---

site_id	AE3
Number of Residues	5
Details	binding site for residue PAM C 904

Chain	Residue
B	PHE607
C	TYR523
C	MET527
C	OLC903
C	PAM905

---

site_id	AE4
Number of Residues	3
Details	binding site for residue PAM C 905

Chain	Residue
C	OLC902
C	PAM904
C	PAM906

---

site_id	AE5
Number of Residues	2
Details	binding site for residue PAM C 906

Chain	Residue
C	PAM905
G	CLR201

---

site_id	AE6
Number of Residues	10
Details	binding site for residue ZK1 D 901

Chain	Residue
D	TYR450
D	PRO478
D	LEU479
D	THR480
D	ARG485
D	GLY653
D	SER654
D	THR686
D	TYR732
D	TYR405

---

site_id	AE7
Number of Residues	2
Details	binding site for residue OLC D 902

Chain	Residue
D	MET527
D	PAM905

---

site_id	AE8
Number of Residues	4
Details	binding site for residue OLC D 903

Chain	Residue
A	SER537
A	VAL538
A	PAM903
D	ARG599

---

site_id	AE9
Number of Residues	5
Details	binding site for residue OLC D 904

Chain	Residue
D	TYR533
D	SER537
D	PHE541
D	ARG545
D	PAM905

---

site_id	AF1
Number of Residues	7
Details	binding site for residue PAM D 905

Chain	Residue
D	TYR523
D	TRP526
D	MET527
D	VAL530
D	OLC902
D	OLC904
D	PAM906

---

site_id	AF2
Number of Residues	3
Details	binding site for residue PAM D 906

Chain	Residue
D	ILE798
D	PAM905
D	PAM907

---

site_id	AF3
Number of Residues	3
Details	binding site for residue PAM D 907

Chain	Residue
D	VAL514
D	PAM906
H	CLR201

---

Functional Information from PROSITE/UniProt

site_id	PS01340
Number of Residues	15
Details	CORNICHON Cornichon family signature. IafdELrtDFkSPID

Chain	Residue	Details
E	ILE29-ASP43

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=M4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---