6PEQ
GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0016192 | biological_process | vesicle-mediated transport |
| E | 0016247 | molecular_function | channel regulator activity |
| E | 0030425 | cellular_component | dendrite |
| E | 0032281 | cellular_component | AMPA glutamate receptor complex |
| E | 0035249 | biological_process | synaptic transmission, glutamatergic |
| E | 0042391 | biological_process | regulation of membrane potential |
| E | 0043198 | cellular_component | dendritic shaft |
| E | 0045202 | cellular_component | synapse |
| E | 0045211 | cellular_component | postsynaptic membrane |
| E | 0051668 | biological_process | localization within membrane |
| E | 0098978 | cellular_component | glutamatergic synapse |
| E | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| E | 2000311 | biological_process | regulation of AMPA receptor activity |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0016192 | biological_process | vesicle-mediated transport |
| F | 0016247 | molecular_function | channel regulator activity |
| F | 0030425 | cellular_component | dendrite |
| F | 0032281 | cellular_component | AMPA glutamate receptor complex |
| F | 0035249 | biological_process | synaptic transmission, glutamatergic |
| F | 0042391 | biological_process | regulation of membrane potential |
| F | 0043198 | cellular_component | dendritic shaft |
| F | 0045202 | cellular_component | synapse |
| F | 0045211 | cellular_component | postsynaptic membrane |
| F | 0051668 | biological_process | localization within membrane |
| F | 0098978 | cellular_component | glutamatergic synapse |
| F | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| F | 2000311 | biological_process | regulation of AMPA receptor activity |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0016192 | biological_process | vesicle-mediated transport |
| G | 0016247 | molecular_function | channel regulator activity |
| G | 0030425 | cellular_component | dendrite |
| G | 0032281 | cellular_component | AMPA glutamate receptor complex |
| G | 0035249 | biological_process | synaptic transmission, glutamatergic |
| G | 0042391 | biological_process | regulation of membrane potential |
| G | 0043198 | cellular_component | dendritic shaft |
| G | 0045202 | cellular_component | synapse |
| G | 0045211 | cellular_component | postsynaptic membrane |
| G | 0051668 | biological_process | localization within membrane |
| G | 0098978 | cellular_component | glutamatergic synapse |
| G | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| G | 2000311 | biological_process | regulation of AMPA receptor activity |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0016192 | biological_process | vesicle-mediated transport |
| H | 0016247 | molecular_function | channel regulator activity |
| H | 0030425 | cellular_component | dendrite |
| H | 0032281 | cellular_component | AMPA glutamate receptor complex |
| H | 0035249 | biological_process | synaptic transmission, glutamatergic |
| H | 0042391 | biological_process | regulation of membrane potential |
| H | 0043198 | cellular_component | dendritic shaft |
| H | 0045202 | cellular_component | synapse |
| H | 0045211 | cellular_component | postsynaptic membrane |
| H | 0051668 | biological_process | localization within membrane |
| H | 0098978 | cellular_component | glutamatergic synapse |
| H | 0099645 | biological_process | neurotransmitter receptor localization to postsynaptic specialization membrane |
| H | 2000311 | biological_process | regulation of AMPA receptor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue ZK1 A 901 |
| Chain | Residue |
| A | TYR405 |
| A | TYR450 |
| A | PRO478 |
| A | LEU479 |
| A | THR480 |
| A | ARG485 |
| A | GLY653 |
| A | SER654 |
| A | TYR732 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 902 |
| Chain | Residue |
| A | TYR523 |
| A | MET527 |
| A | PAM903 |
| A | PAM904 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PAM A 903 |
| Chain | Residue |
| A | TYR523 |
| A | MET527 |
| A | VAL530 |
| A | OLC902 |
| D | OLC903 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PAM A 904 |
| Chain | Residue |
| A | TYR523 |
| A | OLC902 |
| A | PAM905 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue PAM A 905 |
| Chain | Residue |
| A | PAM904 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue ZK1 B 901 |
| Chain | Residue |
| B | TYR405 |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | GLY653 |
| B | SER654 |
| B | THR686 |
| B | TYR732 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue OLC B 902 |
| Chain | Residue |
| B | MET527 |
| B | PAM904 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue OLC B 903 |
| Chain | Residue |
| A | ILE600 |
| B | SER537 |
| B | PAM904 |
| G | LEU69 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue PAM B 904 |
| Chain | Residue |
| B | TYR523 |
| B | MET527 |
| B | ILE798 |
| B | OLC902 |
| B | OLC903 |
| B | PAM905 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PAM B 905 |
| Chain | Residue |
| B | PHE515 |
| B | ILE798 |
| B | PAM904 |
| B | PAM906 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PAM B 906 |
| Chain | Residue |
| B | PAM905 |
| F | CLR201 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CLR E 201 |
| Chain | Residue |
| A | TYR797 |
| E | MET11 |
| E | ALA18 |
| E | LEU157 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CLR F 201 |
| Chain | Residue |
| B | TYR797 |
| B | PAM906 |
| F | LEU14 |
| F | ALA18 |
| F | MET153 |
| F | LEU157 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue PAM F 202 |
| Chain | Residue |
| F | GLN86 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CLR G 201 |
| Chain | Residue |
| C | TYR797 |
| C | PAM906 |
| G | MET11 |
| G | ALA18 |
| G | LEU157 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CLR H 201 |
| Chain | Residue |
| D | TYR797 |
| D | PAM907 |
| H | ALA18 |
| H | LEU157 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue PAM H 202 |
| Chain | Residue |
| H | ILE80 |
| H | GLN86 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue ZK1 C 901 |
| Chain | Residue |
| C | TYR405 |
| C | TYR450 |
| C | PRO478 |
| C | LEU479 |
| C | THR480 |
| C | ARG485 |
| C | GLY653 |
| C | SER654 |
| C | TYR732 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue OLC C 902 |
| Chain | Residue |
| C | TYR523 |
| C | PAM905 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue OLC C 903 |
| Chain | Residue |
| B | SER595 |
| B | ILE600 |
| C | SER537 |
| C | VAL538 |
| C | PAM904 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue PAM C 904 |
| Chain | Residue |
| B | PHE607 |
| C | TYR523 |
| C | MET527 |
| C | OLC903 |
| C | PAM905 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue PAM C 905 |
| Chain | Residue |
| C | OLC902 |
| C | PAM904 |
| C | PAM906 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue PAM C 906 |
| Chain | Residue |
| C | PAM905 |
| G | CLR201 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue ZK1 D 901 |
| Chain | Residue |
| D | TYR450 |
| D | PRO478 |
| D | LEU479 |
| D | THR480 |
| D | ARG485 |
| D | GLY653 |
| D | SER654 |
| D | THR686 |
| D | TYR732 |
| D | TYR405 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue OLC D 902 |
| Chain | Residue |
| D | MET527 |
| D | PAM905 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue OLC D 903 |
| Chain | Residue |
| A | SER537 |
| A | VAL538 |
| A | PAM903 |
| D | ARG599 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue OLC D 904 |
| Chain | Residue |
| D | TYR533 |
| D | SER537 |
| D | PHE541 |
| D | ARG545 |
| D | PAM905 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue PAM D 905 |
| Chain | Residue |
| D | TYR523 |
| D | TRP526 |
| D | MET527 |
| D | VAL530 |
| D | OLC902 |
| D | OLC904 |
| D | PAM906 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue PAM D 906 |
| Chain | Residue |
| D | ILE798 |
| D | PAM905 |
| D | PAM907 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue PAM D 907 |
| Chain | Residue |
| D | VAL514 |
| D | PAM906 |
| H | CLR201 |
Functional Information from PROSITE/UniProt
| site_id | PS01340 |
| Number of Residues | 15 |
| Details | CORNICHON Cornichon family signature. IafdELrtDFkSPID |
| Chain | Residue | Details |
| E | ILE29-ASP43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 212 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| E | MET1-TYR10 | |
| E | ASN94-LYS138 | |
| F | MET1-TYR10 | |
| F | ASN94-LYS138 | |
| G | MET1-TYR10 | |
| G | ASN94-LYS138 | |
| H | MET1-TYR10 | |
| H | ASN94-LYS138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| E | MET11-PHE31 | |
| H | MET11-PHE31 | |
| H | SER73-LEU93 | |
| H | LEU139-SER159 | |
| E | SER73-LEU93 | |
| E | LEU139-SER159 | |
| F | MET11-PHE31 | |
| F | SER73-LEU93 | |
| F | LEU139-SER159 | |
| G | MET11-PHE31 | |
| G | SER73-LEU93 | |
| G | LEU139-SER159 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 164 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| E | ASP32-TYR72 | |
| E | SER160 | |
| F | ASP32-TYR72 | |
| F | SER160 | |
| G | ASP32-TYR72 | |
| G | SER160 | |
| H | ASP32-TYR72 | |
| H | SER160 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | PHE571-ARG586 | |
| B | PHE571-ARG586 | |
| C | PHE571-ARG586 | |
| D | PHE571-ARG586 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLN587-CYS589 | |
| B | GLN587-CYS589 | |
| C | GLN587-CYS589 | |
| D | GLN587-CYS589 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=M4 |
| Chain | Residue | Details |
| A | VAL792-ILE812 | |
| B | VAL792-ILE812 | |
| C | VAL792-ILE812 | |
| D | VAL792-ILE812 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO |
| Chain | Residue | Details |
| A | PRO478 | |
| B | SER654 | |
| B | THR655 | |
| B | GLU705 | |
| C | PRO478 | |
| C | THR480 | |
| C | ARG485 | |
| C | SER654 | |
| C | THR655 | |
| C | GLU705 | |
| D | PRO478 | |
| A | THR480 | |
| D | THR480 | |
| D | ARG485 | |
| D | SER654 | |
| D | THR655 | |
| D | GLU705 | |
| A | ARG485 | |
| A | SER654 | |
| A | THR655 | |
| A | GLU705 | |
| B | PRO478 | |
| B | THR480 | |
| B | ARG485 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG453 | |
| D | ARG453 | |
| D | ARG660 | |
| D | LYS752 | |
| A | ARG660 | |
| A | LYS752 | |
| B | ARG453 | |
| B | ARG660 | |
| B | LYS752 | |
| C | ARG453 | |
| C | ARG660 | |
| C | LYS752 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE633 | |
| B | ILE633 | |
| C | ILE633 | |
| D | ILE633 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | SER662 | |
| B | SER662 | |
| C | SER662 | |
| D | SER662 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | SER696 | |
| B | SER696 | |
| C | SER696 | |
| D | SER696 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819 |
| Chain | Residue | Details |
| A | SER839 | |
| A | SER842 | |
| B | SER839 | |
| B | SER842 | |
| C | SER839 | |
| C | SER842 | |
| D | SER839 | |
| D | SER842 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS589 | |
| A | CYS815 | |
| B | CYS589 | |
| B | CYS815 | |
| C | CYS589 | |
| C | CYS815 | |
| D | CYS589 | |
| D | CYS815 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 |
| Chain | Residue | Details |
| A | ASN235 | |
| B | ASN235 | |
| C | ASN235 | |
| D | ASN235 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ASN349 | |
| B | ASN349 | |
| C | ASN349 | |
| D | ASN349 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN385 | |
| A | ASN392 | |
| B | ASN385 | |
| B | ASN392 | |
| C | ASN385 | |
| C | ASN392 | |
| D | ASN385 | |
| D | ASN392 |
