6P9F

Crystal structure of RAR-related orphan receptor C (NHIS-RORGT(244-487)-L6-SRC1(678-692)) in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 chimera	polymer	285	32886.9	2	UniProt (P51449) UniProt (Q15788) Pfam (PF00104) In PDB	Homo sapiens (Human)	Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR-related orphan receptor C, Retinoid-related orphan receptor-gamma,NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1, SRC-1
2	A, B	trans-4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl}cyclohexane-1-carboxylic acid	non-polymer		627.5	2	Chemie (O5A)
3		water	water		18.0	23	Chemie (HOH)

Sequence modifications

A, B: 265 - 508 (UniProt: P51449)

PDB	External Database	Details
Met 244	-	expression tag
Gly 245	-	expression tag
Ser 246	-	expression tag
Ser 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Ser 254	-	expression tag
Ser 255	-	expression tag
Gly 256	-	expression tag
Leu 257	-	expression tag
Val 258	-	expression tag
Pro 259	-	expression tag
Arg 260	-	expression tag
Gly 261	-	expression tag
Ser 262	-	expression tag
His 263	-	expression tag
Met 264	-	expression tag
Ser 509	-	linker
Gly 510	-	linker
Gly 511	-	linker
Ser 512	-	linker
Gly 513	-	linker
Gly 514	-	linker

A, B: 515 - 528 (UniProt: Q15788)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65773.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1255.1
All*	Total formula weight	67028.9

*Water molecules are not included.