6P95
Structure of Lassa virus glycoprotein in complex with Fab 25.6A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Pre-glycoprotein polyprotein GP complex | polymer | 259 | 29098.4 | 3 | UniProt (P08669) Pfam (PF00798) | Lassa virus (LASV) | |
| 2 | D, F, H (D, F, H) | FAB Antibody heavy chain | polymer | 231 | 24513.4 | 3 | Homo sapiens | ||
| 3 | E, G, I (E, G, L) | FAB Antibody light chain | polymer | 217 | 23052.5 | 3 | Homo sapiens | ||
| 4 | J, K, L (a, b, c) | Pre-glycoprotein polyprotein GP complex | polymer | 180 | 20800.5 | 3 | UniProt (P08669) Pfam (PF00798) | Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) | Pre-GP-C |
| 5 | M, P, S, U (I, M, P, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 6 | AA, DA, N, O, Q... (X, d, J, K, N...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 7 | CA, R, Z (Z, O, W) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 8 | W (T) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
| 9 | X (U) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 10 | BA, EA, Y (Y, e, V) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 11 | FA, GA, HA, IA, JA... (A, B, C, a) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
A, B, C: 1 - 259 (UniProt: P08669)
a, b, c: 260 - 433 (UniProt: P08669)
| PDB | External Database | Details |
|---|---|---|
| Cys 207 | Arg 207 | engineered mutation |
| Arg 258 | Leu 258 | engineered mutation |
| Arg 259 | Leu 259 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 329 | Glu 329 | engineered mutation |
| Thr 332 | Met 332 | engineered mutation |
| Cys 360 | Gly 360 | engineered mutation |
| Glu 434 | - | expression tag |
| Val 435 | - | expression tag |
| Asp 436 | - | expression tag |
| Asp 437 | - | expression tag |
| Asp 438 | - | expression tag |
| Asp 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 292394.7 | |
| Branched | Number of molecules | 19 |
| Total formula weight | 11096.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 305481.9 |
