6P8E
Crystal structure of CDK4 in complex with CyclinD1 and P27
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G1/S-specific cyclin-D1 | polymer | 249 | 28445.3 | 1 | UniProt (P24385) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (Human) | B-cell lymphoma 1 protein,BCL-1,BCL-1 oncogene,PRAD1 oncogene |
| 2 | B (B) | Cyclin-dependent kinase 4 | polymer | 302 | 33947.9 | 1 | UniProt (P11802) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 4,PSK-J3 |
| 3 | C (C) | Cyclin-dependent kinase inhibitor 1B | polymer | 72 | 8772.7 | 1 | UniProt (P46527) Pfam (PF02234) | Homo sapiens (Human) | Cyclin-dependent kinase inhibitor p27,p27Kip1 |
| 4 | D, E (B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, G, H (A, B, C) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
B: 2 - 300 (UniProt: P11802)
C: 25 - 93 (UniProt: P46527)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Phe 1 | - | expression tag |
| - | Gly 42 | deletion |
| - | Gly 43 | deletion |
| - | Gly 44 | deletion |
| Glu 43 | Gly 46 | engineered mutation |
| Glu 44 | Gly 47 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Glu 23 | - | expression tag |
| Phe 24 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 71165.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 48.6 | |
| All* | Total formula weight | 71214.6 |
