6P8E

Crystal structure of CDK4 in complex with CyclinD1 and P27

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	G1/S-specific cyclin-D1	polymer	249	28445.3	1	UniProt (P24385) Pfam (PF00134) Pfam (PF02984) In PDB	Homo sapiens (Human)	B-cell lymphoma 1 protein,BCL-1,BCL-1 oncogene,PRAD1 oncogene
2	B	Cyclin-dependent kinase 4	polymer	302	33947.9	1	UniProt (P11802) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 4,PSK-J3
3	C	Cyclin-dependent kinase inhibitor 1B	polymer	72	8772.7	1	UniProt (P46527) Pfam (PF02234) In PDB	Homo sapiens (Human)	Cyclin-dependent kinase inhibitor p27,p27Kip1
4	B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5		water	water		18.0	194	Chemie (HOH)

Sequence modifications

B: 2 - 300 (UniProt: P11802)

PDB	External Database	Details
Gly -1	-	expression tag
Glu 0	-	expression tag
Phe 1	-	expression tag
-	Gly 42	deletion
-	Gly 43	deletion
-	Gly 44	deletion
Glu 43	Gly 46	engineered mutation
Glu 44	Gly 47	engineered mutation

C: 25 - 93 (UniProt: P46527)

PDB	External Database	Details
Gly 22	-	expression tag
Glu 23	-	expression tag
Phe 24	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	71165.9
Non-Polymers*	Number of molecules	2
	Total formula weight	48.6
All*	Total formula weight	71214.6

*Water molecules are not included.