6P8E
Crystal structure of CDK4 in complex with CyclinD1 and P27
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| B | 0000086 | biological_process | G2/M transition of mitotic cell cycle |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000307 | cellular_component | cyclin-dependent protein kinase holoenzyme complex |
| B | 0000785 | cellular_component | chromatin |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004693 | molecular_function | cyclin-dependent protein serine/threonine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005667 | cellular_component | transcription regulator complex |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005923 | cellular_component | bicellular tight junction |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007165 | biological_process | signal transduction |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0010468 | biological_process | regulation of gene expression |
| B | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030332 | molecular_function | cyclin binding |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| B | 0051301 | biological_process | cell division |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0060260 | biological_process | regulation of transcription initiation by RNA polymerase II |
| B | 0097128 | cellular_component | cyclin D1-CDK4 complex |
| B | 0097129 | cellular_component | cyclin D2-CDK4 complex |
| B | 0106310 | molecular_function | protein serine kinase activity |
| C | 0004861 | molecular_function | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | HIS135 |
| B | ASN142 |
| B | ALA154 |
| B | ASP155 |
| B | PHE156 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | GLY42 |
| B | GLU44 |
| B | GLY45 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK |
| Chain | Residue | Details |
| B | ILE12-LYS35 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV |
| Chain | Residue | Details |
| B | ILE133-VAL145 |
| site_id | PS00292 |
| Number of Residues | 32 |
| Details | CYCLINS Cyclins signature. RkiVatWMlevceeqkCeeevFplAMnYLDRF |
| Chain | Residue | Details |
| A | ARG57-PHE88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | Domain: {"description":"Cyclin N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"40307251","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"Required for binding D-type cyclins"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"17254967","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
