6P6X

Crystal structure of voltage-gated sodium channel NavAb G94C/Q150C mutant in the activated state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ion transport protein	polymer	257	29810.4	1	UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016)	Arcobacter butzleri (strain RM4018)
2	B, C, D, E, F... (A)	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	9	Chemie (PX4)
3	K, L (A)	3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE	non-polymer		614.9	2	Chemie (CPS)

Sequence modifications

A: 1001 - 1239 (UniProt: A8EVM5)

PDB	External Database	Details
Met 983	-	initiating methionine
Asp 984	-	expression tag
Tyr 985	-	expression tag
Lys 986	-	expression tag
Asp 987	-	expression tag
Asp 988	-	expression tag
Asp 989	-	expression tag
Asp 990	-	expression tag
Lys 991	-	expression tag
Gly 992	-	expression tag
Ser 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Cys 1094	Gly 94	engineered mutation
Cys 1150	Gln 150	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29810.4
Non-Polymers*	Number of molecules	11
	Total formula weight	7340.2
All*	Total formula weight	37150.6

*Water molecules are not included.