6P6X
Crystal structure of voltage-gated sodium channel NavAb G94C/Q150C mutant in the activated state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue PX4 A 2001 |
| Chain | Residue |
| A | ILE1134 |
| A | LEU1212 |
| A | PX42002 |
| A | PX42009 |
| A | PHE1141 |
| A | GLY1164 |
| A | GLU1165 |
| A | PHE1167 |
| A | MET1188 |
| A | PRO1192 |
| A | TRP1195 |
| A | MET1209 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue PX4 A 2002 |
| Chain | Residue |
| A | GLY1026 |
| A | GLY1030 |
| A | SER1034 |
| A | LYS1035 |
| A | THR1036 |
| A | LEU1106 |
| A | THR1138 |
| A | TYR1142 |
| A | THR1162 |
| A | GLY1164 |
| A | PX42001 |
| A | CPS2010 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue PX4 A 2003 |
| Chain | Residue |
| A | PHE1144 |
| A | MET1147 |
| A | PHE1152 |
| A | ARG1155 |
| A | VAL1190 |
| A | TYR1191 |
| A | TYR1193 |
| A | ALA1194 |
| A | VAL1196 |
| A | VAL1204 |
| A | PX42004 |
| A | PX42006 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue PX4 A 2004 |
| Chain | Residue |
| A | PRO1075 |
| A | TRP1076 |
| A | PHE1079 |
| A | VAL1120 |
| A | SER1121 |
| A | ILE1124 |
| A | PX42003 |
| A | PX42006 |
| A | PX42007 |
| A | PX42009 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue PX4 A 2005 |
| Chain | Residue |
| A | MET1116 |
| A | PX42006 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 A 2006 |
| Chain | Residue |
| A | PRO1128 |
| A | PX42003 |
| A | PX42004 |
| A | PX42005 |
| A | PX42007 |
| A | PX42009 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue PX4 A 2007 |
| Chain | Residue |
| A | PX42004 |
| A | PX42006 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue PX4 A 2008 |
| Chain | Residue |
| A | PHE1082 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue PX4 A 2009 |
| Chain | Residue |
| A | MET1130 |
| A | PHE1203 |
| A | PHE1207 |
| A | PX42001 |
| A | PX42004 |
| A | PX42006 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CPS A 2010 |
| Chain | Residue |
| A | LEU1031 |
| A | THR1036 |
| A | PHE1037 |
| A | PX42002 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CPS A 2011 |
| Chain | Residue |
| A | SER1012 |
| A | ALA1112 |
| A | PRO1114 |
| A | GLN1115 |
