6P3S
Crystal structure of human Fab H5.28 in complex with influenza A H5N1 Vietnam hemagglutinin head domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, F, I, M... (A, C, F, I, M...) | Human Fab H5.28 heavy chain | polymer | 230 | 24616.7 | 8 | Homo sapiens | ||
| 2 | B, D, G, J, N... (B, D, G, J, N...) | Human Fab H5.28 light chain | polymer | 215 | 23332.8 | 8 | Homo sapiens | ||
| 3 | E, H, K, L, O... (E, H, K, L, O...) | Hemagglutinin | polymer | 219 | 25162.4 | 8 | UniProt (Q1KHK2) Pfam (PF00509) | Influenza A virus (A/chicken/Vietnam/32/2004(H5N1)) | |
| 4 | Y (Y) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1405.3 | 1 | In PDB GlyTouCan (G59070FK) | |||
| 5 | Z (Z) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1405.3 | 1 | In PDB GlyTouCan (G13564MD) | |||
| 6 | AA (a) | N-acetyl-alpha-neuraminic acid-(2-6)-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1202.1 | 1 | In PDB GlyTouCan (G20631NH) | |||
| 7 | BA (b) | N-acetyl-alpha-neuraminic acid-(2-6)-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1405.3 | 1 | In PDB GlyTouCan (G87077ZT) | |||
| 8 | CA (c) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose | branched | 998.9 | 1 | In PDB GlyTouCan (G19798XY) | |||
| 9 | DA (d) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1405.3 | 1 | In PDB GlyTouCan (G77499AE) | |||
| 10 | EA (e) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose | branched | 998.9 | 1 | In PDB GlyTouCan (G89628EO) | |||
| 11 | FA (f) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1405.3 | 1 | In PDB GlyTouCan (G84134OD) | |||
| 12 | GA, HA, IA, JA, KA (L, O, R, U, X) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
E, H, K, L, O, R, U, X: 58 - 268 (UniProt: Q1KHK2)
| PDB | External Database | Details |
|---|---|---|
| Ala 269 | - | expression tag |
| Ala 270 | - | expression tag |
| His 271 | - | expression tag |
| His 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 584895.5 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 10226.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 596227.8 |
