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6P1L

Crystal structure of EGFR in complex with EAI045

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DEpidermal growth factor receptorpolymer32737392.34UniProt (P00533)
Pfam (PF07714)
In PDB
Homo sapiens (Human)Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2A, B, C, DMAGNESIUM IONnon-polymer24.34Chemie (MG)
3A, B, C, DPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.24Chemie (ANP)
4A, C, D(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamidenon-polymer383.43Chemie (9LL)
5waterwater18.012Chemie (HOH)
Sequence modifications
A, B, C, D: 696 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
Met 790Thr 790engineered mutation
Arg 948Val 948engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight149569.1
Non-Polymers*Number of molecules11
Total formula weight3272.2
All*Total formula weight152841.3
*Water molecules are not included.

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PDB entries from 2024-06-12

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