6OX7
The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Non-structural protein 1 | polymer | 145 | 16424.0 | 2 | UniProt (Q99AU3) Pfam (PF00600) | Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) | NS1,NS1A |
| 2 | B, D (C, D) | Phosphatidylinositol 3-kinase regulatory subunit beta | polymer | 165 | 19893.4 | 2 | UniProt (O00459) Pfam (PF16454) | Homo sapiens (Human) | PtdIns-3-kinase regulatory subunit beta,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta,PtdIns-3-kinase regulatory subunit p85-beta |
| 3 | E, F, G, H (A, C, B, D) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B: 86 - 230 (UniProt: Q99AU3)
C, D: 435 - 597 (UniProt: O00459)
| PDB | External Database | Details |
|---|---|---|
| Arg 187 | Trp 187 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 433 | - | expression tag |
| Ser 434 | - | expression tag |
| Ser 501 | Cys 501 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72634.9 | |
| All* | Total formula weight | 72634.9 |
