6OX7

The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Non-structural protein 1	polymer	145	16424.0	2	UniProt (Q99AU3) Pfam (PF00600) In PDB	Influenza A virus (strain A/Brevig Mission/1/1918 H1N1)	NS1,NS1A
2	C, D	Phosphatidylinositol 3-kinase regulatory subunit beta	polymer	165	19893.4	2	UniProt (O00459) Pfam (PF16454) In PDB	Homo sapiens (Human)	PtdIns-3-kinase regulatory subunit beta,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta,PtdIns-3-kinase regulatory subunit p85-beta
3		water	water		18.0	31	Chemie (HOH)

Sequence modifications

A, B: 86 - 230 (UniProt: Q99AU3)

PDB	External Database	Details
Arg 187	Trp 187	engineered mutation

C, D: 435 - 597 (UniProt: O00459)

PDB	External Database	Details
Gly 433	-	expression tag
Ser 434	-	expression tag
Ser 501	Cys 501	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	72634.9
All*	Total formula weight	72634.9

*Water molecules are not included.