6OPP
Asymmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, J (L, I, O) | 17b Fab light chain | polymer | 214 | 23425.9 | 3 | Homo sapiens (Human) | ||
| 2 | B, H, K (B, E, K) | Envelope glycoprotein gp41 | polymer | 153 | 17357.8 | 3 | UniProt (B3UEZ6) Pfam (PF00517) | Human immunodeficiency virus 1 (HIV-1) | |
| 3 | C, G, L (A, D, J) | Envelope glycoprotein gp160 | polymer | 524 | 58872.9 | 3 | UniProt (B3UES2) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 4 | D, M, O (C, M, F) | T-cell surface glycoprotein CD4 | polymer | 208 | 23039.2 | 3 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) | Homo sapiens (Human) | T-cell surface antigen T4/Leu-3 |
| 5 | E, I, N (H, G, N) | 17b Fab heavy chain | polymer | 229 | 24484.5 | 3 | Homo sapiens (Human) | ||
| 6 | AA, BA, EA, FA, HA... (a, b, e, f, h...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 16 | In PDB GlyTouCan (G42666HT) | |||
| 7 | DA, IA, JA, Q, S... (d, i, j, Q, S...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 10 | In PDB GlyTouCan (G15407YE) | |||
| 8 | CA, R (c, R) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G46836GH) | |||
| 9 | GA, RA, V (g, r, V) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 10 | NA (n) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 11 | OA (o) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 12 | BB, OB, WA (B, E) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 3 | Chemie (LMT) | |||
| 13 | AB, CB, DB, EB, FB... (B, A, D, E, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 24 | Chemie (NAG) |
Sequence modifications
B, E, K: 512 - 664 (UniProt: B3UEZ6)
A, D, J: 31 - 513 (UniProt: B3UES2)
C, M, F: 0 - 178 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 563 | engineered mutation |
| Cys 605 | Thr 609 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Asp -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Arg 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Cys 5 | - | expression tag |
| Val 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Val 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Val 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ile 21 | - | expression tag |
| His 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Phe 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Cys 501 | Ala 505 | engineered mutation |
| Arg 509 | Glu 513 | engineered mutation |
| Arg 510 | Lys 514 | engineered mutation |
| Arg 512 | Ala 516 | engineered mutation |
| Arg 513 | Val 517 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
| Glu -18 | - | expression tag |
| Thr -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Thr -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Leu -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Trp -11 | - | expression tag |
| Val -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Trp -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Gly 179 | - | expression tag |
| Gly 180 | - | expression tag |
| Ser 181 | - | expression tag |
| Gly 182 | - | expression tag |
| His 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 441540.7 | |
| Branched | Number of molecules | 33 |
| Total formula weight | 19193.7 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 6840.8 | |
| All* | Total formula weight | 467575.2 |
