6OPN
CD4- and 17-bound HIV-1 Env B41 SOSIP in complex with small molecule GO35
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G | Envelope glycoprotein gp160 | polymer | 524 | 58872.9 | 3 | UniProt (B3UES2) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
2 | B, E, H | Envelope glycoprotein gp41 | polymer | 153 | 17357.8 | 3 | UniProt (B3UEZ6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
3 | C, F, I | T-cell surface glycoprotein CD4 | polymer | 208 | 23039.2 | 3 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB | Homo sapiens (Human) | T-cell surface antigen T4/Leu-3 |
4 | J, L, N | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
5 | K, M, O | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G42227JK) | |||
6 | D, G, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 27 | Chemie (NAG) | |||
7 | E, H, B | [3'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-3-yl](piperidin-1-yl)methanone | non-polymer | 347.4 | 3 | Chemie (N07) |
Sequence modifications
A, D, G: 31 - 513 (UniProt: B3UES2)
B, E, H: 512 - 664 (UniProt: B3UEZ6)
C, F, I: 0 - 178 (UniProt: P01730)
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Lys 0 | - | expression tag |
Arg 1 | - | expression tag |
Gly 2 | - | expression tag |
Leu 3 | - | expression tag |
Cys 4 | - | expression tag |
Cys 5 | - | expression tag |
Val 6 | - | expression tag |
Leu 7 | - | expression tag |
Leu 8 | - | expression tag |
Leu 9 | - | expression tag |
Cys 10 | - | expression tag |
Gly 11 | - | expression tag |
Ala 12 | - | expression tag |
Val 13 | - | expression tag |
Phe 14 | - | expression tag |
Val 15 | - | expression tag |
Ser 16 | - | expression tag |
Pro 17 | - | expression tag |
Ser 18 | - | expression tag |
Gln 19 | - | expression tag |
Glu 20 | - | expression tag |
Ile 21 | - | expression tag |
His 22 | - | expression tag |
Ala 23 | - | expression tag |
Arg 24 | - | expression tag |
Phe 25 | - | expression tag |
Arg 26 | - | expression tag |
Arg 27 | - | expression tag |
Gly 28 | - | expression tag |
Ala 29 | - | expression tag |
Arg 30 | - | expression tag |
Cys 501 | Ala 505 | engineered mutation |
Arg 509 | Glu 513 | engineered mutation |
Arg 510 | Lys 514 | engineered mutation |
Arg 512 | Ala 516 | engineered mutation |
Arg 513 | Val 517 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 563 | engineered mutation |
Cys 605 | Thr 609 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Glu -18 | - | expression tag |
Thr -17 | - | expression tag |
Asp -16 | - | expression tag |
Thr -15 | - | expression tag |
Leu -14 | - | expression tag |
Leu -13 | - | expression tag |
Leu -12 | - | expression tag |
Trp -11 | - | expression tag |
Val -10 | - | expression tag |
Leu -9 | - | expression tag |
Leu -8 | - | expression tag |
Leu -7 | - | expression tag |
Trp -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Thr -1 | - | expression tag |
Gly 179 | - | expression tag |
Gly 180 | - | expression tag |
Ser 181 | - | expression tag |
Gly 182 | - | expression tag |
His 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
His 186 | - | expression tag |
His 187 | - | expression tag |
His 188 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 297809.7 | |
Branched | Number of molecules | 6 |
Total formula weight | 4005.7 | |
Non-Polymers* | Number of molecules | 30 |
Total formula weight | 7014.8 | |
All* | Total formula weight | 308830.2 |