6OM1
Crystal structure of an atypical integrin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Integrin alpha-V | polymer | 599 | 65738.7 | 4 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) | Homo sapiens (Human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
| 2 | B, D, F, H (B, D, F, H) | Integrin beta-8 | polymer | 456 | 50661.4 | 4 | UniProt (P26012) Pfam (PF17205) Pfam (PF00362) | Homo sapiens (Human) | |
| 3 | AA, DA, I, K, O... (a, d, I, K, O...) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 7 | In PDB GlyTouCan (G81315DD) | |||
| 4 | J, U, X (J, U, X) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 5 | L (L) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 6 | EA, FA, GA, M, N... (e, f, g, M, N...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 7 | P, R, W (P, R, W) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G34442SS) | |||
| 8 | BA (b) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G94106MV) | |||
| 9 | CA (c) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 10 | CB, DB, HA, HB, MB... (D, A, E, F, B...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 11 | FB, FC, IA, IB, JA... (D, H, A, E, B...) | CALCIUM ION | non-polymer | 40.1 | 20 | Chemie (CA) | |||
| 12 | AB, AC, BB, BC, CC... (C, G, H, A, E...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 13 | EB, EC, NA, QB (D, H, B, F) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 14 | GB, HC, SA, TB (D, H, B, F) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 4 | Chemie (MES) | |||
| 15 | IC, JC, KC, LC, MC... (A, B, C, D, E...) | water | water | 18.0 | 431 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 595 (UniProt: P06756)
B, D, F, H: 1 - 456 (UniProt: P26012)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | insertion |
| Cys 401 | Met 430 | engineered mutation |
| Thr 596 | - | expression tag |
| Gly 597 | - | expression tag |
| Gly 598 | - | expression tag |
| Leu 599 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 259 | Val 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 465600.7 | |
| Branched | Number of molecules | 25 |
| Total formula weight | 17906.4 | |
| Non-Polymers* | Number of molecules | 53 |
| Total formula weight | 5141.1 | |
| All* | Total formula weight | 488648.1 |
