6OJE
Dimeric structure of LRRK2 GTPase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 206 | 23511.1 | 2 | UniProt (Q5S007) Pfam (PF08477) | Homo sapiens (Human) | Dardarin, LRRK2 |
| 2 | C, E, F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 3 | D, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B: 1329 - 1520 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Met 1315 | - | initiating methionine |
| Gly 1316 | - | expression tag |
| Ser 1317 | - | expression tag |
| Ser 1318 | - | expression tag |
| His 1319 | - | expression tag |
| His 1320 | - | expression tag |
| His 1321 | - | expression tag |
| His 1322 | - | expression tag |
| His 1323 | - | expression tag |
| His 1324 | - | expression tag |
| Ser 1325 | - | expression tag |
| Gln 1326 | - | expression tag |
| Asp 1327 | - | expression tag |
| Pro 1328 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47022.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 983.6 | |
| All* | Total formula weight | 48005.9 |
