6OJE

Dimeric structure of LRRK2 GTPase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Leucine-rich repeat serine/threonine-protein kinase 2	polymer	206	23511.1	2	UniProt (Q5S007) Pfam (PF08477) In PDB	Homo sapiens (Human)	Dardarin, LRRK2
2	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
3	A, B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
4		water	water		18.0	240	Chemie (HOH)

Sequence modifications

A, B: 1329 - 1520 (UniProt: Q5S007)

PDB	External Database	Details
Met 1315	-	initiating methionine
Gly 1316	-	expression tag
Ser 1317	-	expression tag
Ser 1318	-	expression tag
His 1319	-	expression tag
His 1320	-	expression tag
His 1321	-	expression tag
His 1322	-	expression tag
His 1323	-	expression tag
His 1324	-	expression tag
Ser 1325	-	expression tag
Gln 1326	-	expression tag
Asp 1327	-	expression tag
Pro 1328	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47022.3
Non-Polymers*	Number of molecules	6
	Total formula weight	983.6
All*	Total formula weight	48005.9

*Water molecules are not included.