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6OIQ

Crystal structure of MYST acetyltransferase domain in complex with inhibitor 63

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Histone acetyltransferase KAT8polymer27332140.11UniProt (Q9H7Z6)
Pfam (PF17772)
Pfam (PF01853)
Homo sapiens (Human)Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C
(A)
2-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazidenon-polymer370.41Chemie (MLV)
4D
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
5E
(A)
waterwater18.0165Chemie (HOH)
Sequence modifications
A: 506 - 778 (UniProt: Q9H7Z6)
PDBExternal DatabaseDetails
His 579Tyr 249conflict
Ser 645Ala 315engineered mutation
Met 648Leu 318engineered mutation
Ile 649Thr 319engineered mutation
Arg 660Lys 330engineered mutation
Asn 702Ile 372conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight32140.1
Non-Polymers*Number of molecules3
Total formula weight527.9
All*Total formula weight32668.0
*Water molecules are not included.

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PDB entries from 2025-07-23

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