6OGE

Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Receptor tyrosine-protein kinase erbB-2	polymer	622	68536.8	1	UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (Human)	Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2
2	B (B)	Pertuzumab FAB LIGHT CHAIN	polymer	214	23548.2	1	UniProt (P01834) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	Pertuzumab FAB HEAVY CHAIN	polymer	222	23674.5	1	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
4	D (D)	Trastuzumab FAB LIGHT CHAIN	polymer	214	23466.0	1	UniProt (P01834) Pfam (PF07654)	Homo sapiens (Human)
5	E (E)	Trastuzumab FAB HEAVY CHAIN	polymer	220	23425.2	1	UniProt (Q6GMX6) Pfam (PF07654) Pfam (PF07686)	Homo sapiens (Human)
6	F (F)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
7	G, H, I, J, K (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)

Sequence modifications

B: 1 - 107 (PDB: 6OGE)
B: 108 - 214 (UniProt: P01834)
C: 1 - 102 (PDB: 6OGE)
C: 103 - 216 (UniProt: P0DOX5)
D: 1 - 107 (PDB: 6OGE)
D: 108 - 214 (UniProt: P01834)
E: 1 - 108 (PDB: 6OGE)
E: 109 - 220 (UniProt: Q6GMX6)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	162650.7
Branched	Number of molecules	1
	Total formula weight	748.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	164505.4

*Water molecules are not included.