6OGE
Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Receptor tyrosine-protein kinase erbB-2 | polymer | 622 | 68536.8 | 1 | UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB | Homo sapiens (Human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
2 | B | Pertuzumab FAB LIGHT CHAIN | polymer | 214 | 23548.2 | 1 | UniProt (P01834) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C | Pertuzumab FAB HEAVY CHAIN | polymer | 222 | 23674.5 | 1 | UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
4 | D | Trastuzumab FAB LIGHT CHAIN | polymer | 214 | 23466.0 | 1 | UniProt (P01834) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
5 | E | Trastuzumab FAB HEAVY CHAIN | polymer | 220 | 23425.2 | 1 | UniProt (Q6GMX6) Pfam (PF07654) Pfam (PF07686) In PDB | Homo sapiens (Human) | |
6 | F | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
B: 1 - 107 (PDB: 6OGE)
B: 108 - 214 (UniProt: P01834)
C: 1 - 102 (PDB: 6OGE)
C: 103 - 216 (UniProt: P0DOX5)
D: 1 - 107 (PDB: 6OGE)
D: 108 - 214 (UniProt: P01834)
E: 1 - 108 (PDB: 6OGE)
E: 109 - 220 (UniProt: Q6GMX6)
B: 108 - 214 (UniProt: P01834)
C: 1 - 102 (PDB: 6OGE)
C: 103 - 216 (UniProt: P0DOX5)
D: 1 - 107 (PDB: 6OGE)
D: 108 - 214 (UniProt: P01834)
E: 1 - 108 (PDB: 6OGE)
E: 109 - 220 (UniProt: Q6GMX6)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 162650.7 | |
Branched | Number of molecules | 1 |
Total formula weight | 748.7 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1106.0 | |
All* | Total formula weight | 164505.4 |