6OGE
Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0003823 | molecular_function | antigen binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0016064 | biological_process | immunoglobulin mediated immune response |
| B | 0019814 | cellular_component | immunoglobulin complex |
| B | 0050853 | biological_process | B cell receptor signaling pathway |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071735 | cellular_component | IgG immunoglobulin complex |
| B | 0071738 | cellular_component | IgD immunoglobulin complex |
| B | 0071742 | cellular_component | IgE immunoglobulin complex |
| B | 0071745 | cellular_component | IgA immunoglobulin complex |
| B | 0071753 | cellular_component | IgM immunoglobulin complex |
| B | 0072562 | cellular_component | blood microparticle |
| D | 0002250 | biological_process | adaptive immune response |
| D | 0002376 | biological_process | immune system process |
| D | 0003823 | molecular_function | antigen binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006955 | biological_process | immune response |
| D | 0016020 | cellular_component | membrane |
| D | 0016064 | biological_process | immunoglobulin mediated immune response |
| D | 0019814 | cellular_component | immunoglobulin complex |
| D | 0050853 | biological_process | B cell receptor signaling pathway |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071735 | cellular_component | IgG immunoglobulin complex |
| D | 0071738 | cellular_component | IgD immunoglobulin complex |
| D | 0071742 | cellular_component | IgE immunoglobulin complex |
| D | 0071745 | cellular_component | IgA immunoglobulin complex |
| D | 0071753 | cellular_component | IgM immunoglobulin complex |
| D | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| C | TYR194-HIS200 | |
| E | TYR201-HIS207 | |
| B | TYR192-HIS198 | |
| D | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:826475 |
| Chain | Residue | Details |
| C | GLU1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASP72 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN124 | |
| A | ASN629 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85 |
| Chain | Residue | Details |
| A | ASN187 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0000269|PubMed:20696930, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW, ECO:0007744|PDB:3N85 |
| Chain | Residue | Details |
| A | ASN259 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0007744|PDB:1S78 |
| Chain | Residue | Details |
| A | ASN530 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:3MZW |
| Chain | Residue | Details |
| A | ASN571 |
