6OEJ
CRYSTAL STRUCTURE OF THE NON-NEUTRALIZING AND ADCC-POTENT ANTIBODY C11 IN COMPLEX WITH HIV-1 CLADE A/E GP120
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | G, A | clade A/E 93TH057 HIV-1 gp120 core | polymer | 385 | 42852.8 | 2 | UniProt (A0A0M3KKW9) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
| 2 | H, B | C11 Fab heavy chain | polymer | 239 | 25642.6 | 2 | Homo sapiens | ||
| 3 | L, C | C11 Fab light chain | polymer | 218 | 23710.5 | 2 | Homo sapiens | ||
| 4 | D, E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 5 | A, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 22 | Chemie (NAG) |
Sequence modifications
G, A: 44 - 492 (UniProt: A0A0M3KKW9)
| PDB | External Database | Details |
|---|---|---|
| Cys 31 | - | see sequence details |
| Asp 32 | - | see sequence details |
| Asn 33 | - | see sequence details |
| Leu 34 | - | see sequence details |
| Trp 35 | - | see sequence details |
| Val 36 | - | see sequence details |
| Thr 37 | - | see sequence details |
| Val 38 | - | see sequence details |
| Tyr 39 | - | see sequence details |
| Tyr 40 | - | see sequence details |
| Gly 41 | - | see sequence details |
| Val 42 | - | see sequence details |
| Pro 43 | - | see sequence details |
| Cys 80 | Asn 37 | engineered mutation |
| Ser 375 | His 242 | engineered mutation |
| Pro 493 | - | see sequence details |
| Leu 494 | - | see sequence details |
| Gly 495 | - | see sequence details |
| Ile 496 | - | see sequence details |
| Ala 497 | - | see sequence details |
| Pro 498 | - | see sequence details |
| Thr 499 | - | see sequence details |
| Lys 500 | - | see sequence details |
| Ala 501 | - | see sequence details |
| Lys 502 | - | see sequence details |
| Arg 503 | - | see sequence details |
| Arg 504 | - | see sequence details |
| Val 505 | - | see sequence details |
| Val 506 | - | see sequence details |
| Gln 507 | - | see sequence details |
| Arg 508 | - | see sequence details |
| Glu 509 | - | see sequence details |
| Lys 510 | - | see sequence details |
| Arg 511 | - | see sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 184411.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1465.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 4866.6 | |
| All* | Total formula weight | 190743.7 |
