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6OEA

Crystal structure of HMCES SRAP domain in complex with longer 3' overhang DNA

Replaces:  6NLC
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding proteinpolymer27631671.61UniProt (Q96FZ2)
Pfam (PF02586)
Homo sapiens (Human)ES cell-specific 5hmC-binding protein,Putative peptidase SRAPD1,SRAP domain-containing protein 1
2B
(B)
DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*TP*GP*TP*T)-3')polymer123653.41synthetic construct
3C
(C)
DNA (5'-D(*GP*TP*CP*TP*GP*G)-3')polymer61840.21synthetic construct
4D, E, F, G, S
(A, C)
1,2-ETHANEDIOLnon-polymer62.15Chemie (EDO)
5H, I, J, K, L...
(A, B)
UNKNOWN ATOM OR IONnon-polymer11Chemie (UNX)
6T, U
(A, B)
waterwater18.046Chemie (HOH)
Sequence modifications
A: 2 - 270 (UniProt: Q96FZ2)
PDBExternal DatabaseDetails
Ala 271-expression tag
Glu 272-expression tag
Asn 273-expression tag
Leu 274-expression tag
Tyr 275-expression tag
Phe 276-expression tag
Gln 277-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight37165.2
Non-Polymers*Number of molecules16
Total formula weight310.3
All*Total formula weight37475.6
*Water molecules are not included.

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PDB entries from 2025-12-24

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