6OE7
Crystal structure of HMCES cross-linked to DNA abasic site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein | polymer | 276 | 31671.6 | 1 | UniProt (Q96FZ2) Pfam (PF02586) | Homo sapiens (Human) | ES cell-specific 5hmC-binding protein,Putative peptidase SRAPD1,SRAP domain-containing protein 1 |
| 2 | B (C) | DNA (5'-D(*GP*TP*CP*TP*GP*G)-3') | polymer | 6 | 1840.2 | 1 | synthetic construct | ||
| 3 | C (B) | DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*(DRZ)P*GP*TP*T)-3') | polymer | 12 | 3545.3 | 1 | synthetic construct | ||
| 4 | D, H, K, L (A, B) | UNKNOWN ATOM OR ION | non-polymer | 4 | Chemie (UNX) | ||||
| 5 | E, F, G, I, J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 2 - 270 (UniProt: Q96FZ2)
| PDB | External Database | Details |
|---|---|---|
| Ala 271 | - | expression tag |
| Glu 272 | - | expression tag |
| Asn 273 | - | expression tag |
| Leu 274 | - | expression tag |
| Tyr 275 | - | expression tag |
| Phe 276 | - | expression tag |
| Gln 277 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 37057.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 310.3 | |
| All* | Total formula weight | 37367.5 |
