6OE7
Crystal structure of HMCES cross-linked to DNA abasic site
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ALA17 |
| A | CYS18 |
| A | LEU53 |
| A | ARG68 |
| A | LEU173 |
| A | THR175 |
| A | GLU220 |
| A | HOH409 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ASN49 |
| A | TYR193 |
| A | LYS37 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ARG16 |
| A | ASP34 |
| A | PRO35 |
| A | ASP36 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | THR248 |
| A | PHE249 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | GLN47 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"31235913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30554877","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"37519246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37950866","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for sensing abasic sites","evidences":[{"source":"UniProtKB","id":"P76318","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required to stabilize abasic sites","evidences":[{"source":"UniProtKB","id":"P76318","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Thiazolidine linkage to a ring-opened DNA abasic site","evidences":[{"source":"PubMed","id":"31235913","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
