6OE5
Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fusion glycoprotein F0,Fibritin | polymer | 553 | 61370.3 | 1 | UniProt (P03420) UniProt (P10104) Pfam (PF00523) | Human respiratory syncytial virus A (strain A2) | prefusion RSV F, Protein F,Collar protein,Whisker antigen control protein |
| 2 | B (B) | Motavizumab Fab Heavy Chain | polymer | 225 | 24284.5 | 1 | Mus musculus | ||
| 3 | C (C) | Motavizumab Fab Light Chain | polymer | 213 | 23150.7 | 1 | Mus musculus | ||
| 4 | D (H) | CR9501 Fab Heavy Chain | polymer | 230 | 24367.3 | 1 | Homo sapiens | ||
| 5 | E (L) | CR9501 Fab Light Chain | polymer | 214 | 23557.1 | 1 | Homo sapiens |
Sequence modifications
A: 1 - 513 (UniProt: P03420)
A: 518 - 544 (UniProt: P10104)
| PDB | External Database | Details |
|---|---|---|
| Ile 67 | Asn 67 | engineered mutation |
| Pro 215 | Ser 215 | engineered mutation |
| Ser 514 | - | linker |
| Ala 515 | - | linker |
| Ile 516 | - | linker |
| Gly 517 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 539 | Phe 479 | conflict |
| Gly 545 | - | expression tag |
| Ser 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Glu 548 | - | expression tag |
| Val 549 | - | expression tag |
| Leu 550 | - | expression tag |
| Phe 551 | - | expression tag |
| Gln 552 | - | expression tag |
| Gly 553 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 156729.9 | |
| All* | Total formula weight | 156729.9 |
