6OCW
Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A85
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Proteasome subunit alpha | polymer | 240 | 25972.0 | 14 | UniProt (P9WHU1) Pfam (PF00227) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 20S proteasome alpha subunit, Proteasome core protein PrcA |
| 2 | AA, BA, H, I, J... (H, I, J, K, L...) | Proteasome subunit beta | polymer | 234 | 24445.4 | 14 | UniProt (P9WHT9) Pfam (PF00227) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 20S proteasome beta subunit, Proteasome core protein PrcB |
| 3 | AB, BB, CA, CB, DA... (R, S, A, T, C...) | DIMETHYLFORMAMIDE | non-polymer | 73.1 | 15 | Chemie (DMF) | |||
| 4 | EB, GB, HA, IB, JA... (V, W, H, X, I...) | N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-4-[(2S)-2-methylpiperidin-1-yl]-1,4-dioxobutan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name) | non-polymer | 519.5 | 14 | Chemie (M6M) | |||
| 5 | FB, HB, IA, JB, KA... (V, W, H, X, I...) | CITRIC ACID | non-polymer | 192.1 | 14 | Chemie (CIT) | |||
| 6 | AC, BC, CC, DC, EC... (H, I, J, K, L...) | water | water | 18.0 | 937 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, O, P, Q, R, S, T, U: 10 - 248 (UniProt: P9WHU1)
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 705843.0 | |
| Non-Polymers* | Number of molecules | 43 |
| Total formula weight | 11059.7 | |
| All* | Total formula weight | 716902.7 |
