6OCW

Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A85

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030682	biological_process	symbiont-mediated perturbation of host defenses
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030682	biological_process	symbiont-mediated perturbation of host defenses
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0019941	biological_process	modification-dependent protein catabolic process
C	0030682	biological_process	symbiont-mediated perturbation of host defenses
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030682	biological_process	symbiont-mediated perturbation of host defenses
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0005886	cellular_component	plasma membrane
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0019941	biological_process	modification-dependent protein catabolic process
E	0030682	biological_process	symbiont-mediated perturbation of host defenses
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019941	biological_process	modification-dependent protein catabolic process
F	0030682	biological_process	symbiont-mediated perturbation of host defenses
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0005886	cellular_component	plasma membrane
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0019941	biological_process	modification-dependent protein catabolic process
G	0030682	biological_process	symbiont-mediated perturbation of host defenses
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0010498	biological_process	proteasomal protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005839	cellular_component	proteasome core complex
I	0010498	biological_process	proteasomal protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0010498	biological_process	proteasomal protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005839	cellular_component	proteasome core complex
L	0010498	biological_process	proteasomal protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005839	cellular_component	proteasome core complex
M	0010498	biological_process	proteasomal protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0010498	biological_process	proteasomal protein catabolic process
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0004175	molecular_function	endopeptidase activity
O	0004298	molecular_function	threonine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005839	cellular_component	proteasome core complex
O	0005886	cellular_component	plasma membrane
O	0009274	cellular_component	peptidoglycan-based cell wall
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0019941	biological_process	modification-dependent protein catabolic process
O	0030682	biological_process	symbiont-mediated perturbation of host defenses
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0004175	molecular_function	endopeptidase activity
P	0004298	molecular_function	threonine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005839	cellular_component	proteasome core complex
P	0005886	cellular_component	plasma membrane
P	0009274	cellular_component	peptidoglycan-based cell wall
P	0010498	biological_process	proteasomal protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0019941	biological_process	modification-dependent protein catabolic process
P	0030682	biological_process	symbiont-mediated perturbation of host defenses
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0004175	molecular_function	endopeptidase activity
Q	0004298	molecular_function	threonine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005839	cellular_component	proteasome core complex
Q	0005886	cellular_component	plasma membrane
Q	0009274	cellular_component	peptidoglycan-based cell wall
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0019941	biological_process	modification-dependent protein catabolic process
Q	0030682	biological_process	symbiont-mediated perturbation of host defenses
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0004175	molecular_function	endopeptidase activity
R	0004298	molecular_function	threonine-type endopeptidase activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005839	cellular_component	proteasome core complex
R	0005886	cellular_component	plasma membrane
R	0009274	cellular_component	peptidoglycan-based cell wall
R	0010498	biological_process	proteasomal protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0019941	biological_process	modification-dependent protein catabolic process
R	0030682	biological_process	symbiont-mediated perturbation of host defenses
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0004175	molecular_function	endopeptidase activity
S	0004298	molecular_function	threonine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005839	cellular_component	proteasome core complex
S	0005886	cellular_component	plasma membrane
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0019941	biological_process	modification-dependent protein catabolic process
S	0030682	biological_process	symbiont-mediated perturbation of host defenses
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0004175	molecular_function	endopeptidase activity
T	0004298	molecular_function	threonine-type endopeptidase activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005839	cellular_component	proteasome core complex
T	0005886	cellular_component	plasma membrane
T	0009274	cellular_component	peptidoglycan-based cell wall
T	0010498	biological_process	proteasomal protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0019941	biological_process	modification-dependent protein catabolic process
T	0030682	biological_process	symbiont-mediated perturbation of host defenses
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0051603	biological_process	proteolysis involved in protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0004175	molecular_function	endopeptidase activity
U	0004298	molecular_function	threonine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005839	cellular_component	proteasome core complex
U	0005886	cellular_component	plasma membrane
U	0009274	cellular_component	peptidoglycan-based cell wall
U	0010498	biological_process	proteasomal protein catabolic process
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0019941	biological_process	modification-dependent protein catabolic process
U	0030682	biological_process	symbiont-mediated perturbation of host defenses
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0010498	biological_process	proteasomal protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005839	cellular_component	proteasome core complex
W	0010498	biological_process	proteasomal protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005839	cellular_component	proteasome core complex
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005839	cellular_component	proteasome core complex
a	0010498	biological_process	proteasomal protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005839	cellular_component	proteasome core complex
b	0010498	biological_process	proteasomal protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue DMF A 301

Chain	Residue
A	ARG76
G	ARG85
G	ASN101
G	GLN105

---

site_id	AC2
Number of Residues	3
Details	binding site for residue DMF C 301

Chain	Residue
C	GLY77
C	TYR103
C	HOH413

---

site_id	AC3
Number of Residues	4
Details	binding site for residue DMF D 301

Chain	Residue
D	TYR103
D	THR106
D	GLY77
D	GLY78

---

site_id	AC4
Number of Residues	4
Details	binding site for residue DMF E 301

Chain	Residue
E	GLY77
E	GLY78
E	TYR103
E	THR106

---

site_id	AC5
Number of Residues	4
Details	binding site for residue DMF F 301

Chain	Residue
F	ARG85
F	TYR89
N	TYR66
N	HOH415

---

site_id	AC6
Number of Residues	24
Details	binding site for residue M6M H 301

Chain	Residue
H	THR1
H	ARG19
H	SER20
H	THR21
H	GLN22
H	SER27
H	VAL31
H	ARG32
H	LYS33
H	ILE45
H	GLY47
H	THR48
H	ALA49
H	ALA52
H	VAL53
H	CIT302
H	HOH412
I	PHE123
I	ASP124
I	ALA125
I	ALA126
I	GLY128
I	TRP129
I	HOH401

---

site_id	AC7
Number of Residues	10
Details	binding site for residue CIT H 302

Chain	Residue
H	THR1
H	THR21
H	ALA46
H	GLY47
H	GLY140
H	SER141
H	ALA180
H	M6M301
H	HOH429
Y	ASN24

---

site_id	AC8
Number of Residues	21
Details	binding site for residue M6M I 301

Chain	Residue
I	THR1
I	SER20
I	THR21
I	GLN22
I	SER27
I	VAL31
I	ARG32
I	LYS33
I	ILE45
I	GLY47
I	ALA49
I	ALA52
I	VAL53
I	CIT302
I	HOH416
J	SER122
J	ASP124
J	ALA125
J	ALA126
J	GLY128
J	TRP129

---

site_id	AC9
Number of Residues	8
Details	binding site for residue CIT I 302

Chain	Residue
I	THR1
I	ALA46
I	GLY47
I	GLY140
I	SER141
I	ALA180
I	M6M301
X	ASN24

---

site_id	AD1
Number of Residues	23
Details	binding site for residue M6M J 301

Chain	Residue
K	ASP124
K	ALA125
K	ALA126
K	GLY128
K	TRP129
K	HOH408
J	THR1
J	ARG19
J	SER20
J	THR21
J	GLN22
J	SER27
J	VAL31
J	ARG32
J	LYS33
J	ILE45
J	GLY47
J	ALA49
J	ALA52
J	VAL53
J	CIT302
K	SER122
K	PHE123

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CIT J 302

Chain	Residue
J	THR1
J	ALA46
J	GLY47
J	SER141
J	M6M301

---

site_id	AD3
Number of Residues	5
Details	binding site for residue DMF J 303

Chain	Residue
B	ARG85
B	TYR89
J	TYR66
J	LEU69
J	GLU70

---

site_id	AD4
Number of Residues	22
Details	binding site for residue M6M K 301

Chain	Residue
K	THR1
K	SER20
K	THR21
K	GLN22
K	SER27
K	VAL31
K	ARG32
K	LYS33
K	ILE45
K	GLY47
K	THR48
K	ALA49
K	ALA52
K	VAL53
K	CIT302
K	HOH420
L	SER122
L	ASP124
L	ALA125
L	ALA126
L	GLY128
L	TRP129

---

site_id	AD5
Number of Residues	7
Details	binding site for residue CIT K 302

Chain	Residue
K	THR1
K	GLY47
K	GLY140
K	SER141
K	ALA180
K	M6M301
V	ASN24

---

site_id	AD6
Number of Residues	23
Details	binding site for residue M6M L 301

Chain	Residue
L	THR1
L	ARG19
L	SER20
L	THR21
L	GLN22
L	SER27
L	VAL31
L	ARG32
L	LYS33
L	ILE45
L	GLY47
L	THR48
L	ALA49
L	ALA52
L	VAL53
L	CIT302
L	HOH434
M	PHE123
M	ASP124
M	ALA125
M	GLY128
M	TRP129
M	HOH404

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CIT L 302

Chain	Residue
L	THR1
L	GLY47
L	SER141
L	M6M301
L	HOH434
b	ASN24

---

site_id	AD8
Number of Residues	22
Details	binding site for residue M6M M 301

Chain	Residue
M	THR1
M	ARG19
M	SER20
M	THR21
M	GLN22
M	SER27
M	VAL31
M	LYS33
M	ILE45
M	GLY47
M	THR48
M	ALA49
M	ALA52
M	VAL53
M	CIT302
M	HOH445
N	ASP124
N	ALA125
N	ALA126
N	GLY128
N	TRP129
N	HOH426

---

site_id	AD9
Number of Residues	8
Details	binding site for residue CIT M 302

Chain	Residue
M	THR1
M	THR21
M	ALA46
M	GLY47
M	GLY140
M	SER141
M	ALA180
M	M6M301

---

site_id	AE1
Number of Residues	24
Details	binding site for residue M6M N 301

Chain	Residue
H	SER122
H	PHE123
H	ASP124
H	ALA125
H	ALA126
H	GLY128
H	TRP129
H	ASN130
H	HOH406
N	THR1
N	SER20
N	THR21
N	GLN22
N	SER27
N	VAL31
N	ARG32
N	LYS33
N	ILE45
N	GLY47
N	THR48
N	ALA49
N	ALA52
N	VAL53
N	CIT302

---

site_id	AE2
Number of Residues	5
Details	binding site for residue CIT N 302

Chain	Residue
N	THR1
N	GLY47
N	SER141
N	M6M301
Z	ASN24

---

site_id	AE3
Number of Residues	5
Details	binding site for residue DMF O 301

Chain	Residue
O	ARG85
O	TYR89
W	HIS65
W	TYR66
W	GLU70

---

site_id	AE4
Number of Residues	4
Details	binding site for residue DMF P 301

Chain	Residue
P	ARG85
P	TYR89
X	TYR66
X	GLU70

---

site_id	AE5
Number of Residues	5
Details	binding site for residue DMF Q 301

Chain	Residue
Q	ARG85
Q	TYR89
Y	TYR66
Y	LEU69
Y	GLU70

---

site_id	AE6
Number of Residues	4
Details	binding site for residue DMF R 301

Chain	Residue
R	LEU74
R	GLY77
R	TYR103
R	THR106

---

site_id	AE7
Number of Residues	6
Details	binding site for residue DMF R 302

Chain	Residue
R	ARG85
R	TYR89
Z	HIS65
Z	TYR66
Z	LEU69
Z	GLU70

---

site_id	AE8
Number of Residues	4
Details	binding site for residue DMF S 301

Chain	Residue
S	LEU74
S	GLY77
S	VAL102
S	THR106

---

site_id	AE9
Number of Residues	4
Details	binding site for residue DMF T 301

Chain	Residue
T	GLY77
T	GLY78
T	TYR103
T	THR106

---

site_id	AF1
Number of Residues	3
Details	binding site for residue DMF U 301

Chain	Residue
U	GLY77
U	VAL102
U	THR106

---

site_id	AF2
Number of Residues	21
Details	binding site for residue M6M V 301

Chain	Residue
V	THR1
V	SER20
V	THR21
V	GLN22
V	SER27
V	VAL31
V	ARG32
V	ILE45
V	GLY47
V	ALA49
V	ALA52
V	VAL53
V	CIT302
W	SER122
W	PHE123
W	ASP124
W	ALA125
W	ALA126
W	GLY128
W	TRP129
W	HOH406

---

site_id	AF3
Number of Residues	5
Details	binding site for residue CIT V 302

Chain	Residue
V	THR1
V	GLY47
V	GLY140
V	SER141
V	M6M301

---

site_id	AF4
Number of Residues	23
Details	binding site for residue M6M W 301

Chain	Residue
W	THR1
W	SER20
W	THR21
W	GLN22
W	SER27
W	VAL31
W	ARG32
W	LYS33
W	ILE45
W	GLY47
W	THR48
W	ALA49
W	ALA52
W	VAL53
W	CIT302
W	HOH421
X	SER122
X	PHE123
X	ASP124
X	ALA125
X	ALA126
X	GLY128
X	TRP129

---

site_id	AF5
Number of Residues	5
Details	binding site for residue CIT W 302

Chain	Residue
J	ASN24
W	THR1
W	GLY47
W	SER141
W	M6M301

---

site_id	AF6
Number of Residues	23
Details	binding site for residue M6M X 301

Chain	Residue
X	THR1
X	ARG19
X	SER20
X	THR21
X	GLN22
X	SER27
X	VAL31
X	ARG32
X	LYS33
X	ILE45
X	GLY47
X	THR48
X	ALA49
X	ALA52
X	VAL53
X	CIT302
X	HOH435
Y	SER122
Y	PHE123
Y	ASP124
Y	ALA126
Y	GLY128
Y	TRP129

---

site_id	AF7
Number of Residues	8
Details	binding site for residue CIT X 302

Chain	Residue
X	THR1
X	THR21
X	ALA46
X	GLY47
X	GLY140
X	SER141
X	M6M301
X	HOH435

---

site_id	AF8
Number of Residues	20
Details	binding site for residue M6M Y 301

Chain	Residue
Y	THR1
Y	SER20
Y	THR21
Y	GLN22
Y	SER27
Y	ARG32
Y	ILE45
Y	GLY47
Y	ALA49
Y	ALA52
Y	VAL53
Y	CIT302
Z	PHE123
Z	ASP124
Z	ALA125
Z	ALA126
Z	GLY128
Z	TRP129
Z	HOH416
Z	HOH418

---

site_id	AF9
Number of Residues	6
Details	binding site for residue CIT Y 302

Chain	Residue
Y	THR1
Y	ALA46
Y	GLY47
Y	GLY140
Y	SER141
Y	M6M301

---

site_id	AG1
Number of Residues	22
Details	binding site for residue M6M Z 301

Chain	Residue
Z	THR1
Z	ARG19
Z	SER20
Z	THR21
Z	GLN22
Z	SER27
Z	VAL31
Z	ARG32
Z	LYS33
Z	ILE45
Z	GLY47
Z	ALA49
Z	ALA52
Z	VAL53
Z	CIT302
Z	HOH437
a	PHE123
a	ASP124
a	ALA125
a	GLY128
a	TRP129
a	HOH401

---

site_id	AG2
Number of Residues	5
Details	binding site for residue CIT Z 302

Chain	Residue
Z	THR1
Z	GLY47
Z	SER141
Z	M6M301
Z	HOH437

---

site_id	AG3
Number of Residues	23
Details	binding site for residue M6M a 301

Chain	Residue
a	THR1
a	ARG19
a	SER20
a	THR21
a	GLN22
a	SER27
a	VAL31
a	ARG32
a	LYS33
a	ILE45
a	GLY47
a	THR48
a	ALA49
a	ALA52
a	VAL53
a	CIT302
b	PHE123
b	ASP124
b	ALA125
b	ALA126
b	GLY128
b	TRP129
b	HOH404

---

site_id	AG4
Number of Residues	7
Details	binding site for residue CIT a 302

Chain	Residue
a	THR1
a	THR21
a	GLY47
a	SER141
a	ALA180
a	M6M301
a	HOH427

---

site_id	AG5
Number of Residues	5
Details	binding site for residue DMF a 303

Chain	Residue
S	ARG85
S	TYR89
a	HIS65
a	TYR66
a	GLU70

---

site_id	AG6
Number of Residues	21
Details	binding site for residue M6M b 301

Chain	Residue
V	PHE123
V	ASP124
V	ALA125
V	ALA126
V	GLY128
V	TRP129
b	THR1
b	SER20
b	THR21
b	GLN22
b	SER27
b	VAL31
b	ARG32
b	LYS33
b	ILE45
b	GLY47
b	THR48
b	ALA49
b	ALA52
b	VAL53
b	CIT302

---

site_id	AG7
Number of Residues	6
Details	binding site for residue CIT b 302

Chain	Residue
b	THR1
b	THR21
b	GLY47
b	SER141
b	M6M301
b	HOH424

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25224505","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20711362","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Site: {"description":"Covalent link with the inhibitor MLN-273","evidences":[{"source":"PubMed","id":"16468986","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---