6OBA

The beta2 adrenergic receptor bound to a negative allosteric modulator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor	polymer	500	56601.4	1	UniProt (P07550) UniProt (D9IEF7) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (Human)	Beta-2 adrenoreceptor,Beta-2 adrenoceptor
2	A	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
3	A	(2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol	non-polymer		249.3	1	Chemie (JTZ)
4	A	6-bromo-N~2~-phenylquinazoline-2,4-diamine	non-polymer		315.2	1	Chemie (M3J)

Sequence modifications

A: 1 - 230 (UniProt: P07550)

PDB	External Database	Details
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Ala 0	-	expression tag
Arg 16	Gly 16	variant
Gln 27	Glu 27	variant
Glu 187	Asn 187	engineered mutation

A: 1002 - 263 (UniProt: D9IEF7)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A: 264 - 365 (UniProt: P07550)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56601.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1337.8
All*	Total formula weight	57939.3

*Water molecules are not included.