6OBA

The beta2 adrenergic receptor bound to a negative allosteric modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004941	molecular_function	beta2-adrenergic receptor activity
A	0006940	biological_process	regulation of smooth muscle contraction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis
A	0097746	biological_process	blood vessel diameter maintenance

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CLR A 1201

Chain	Residue
A	THR73
A	CYS77
A	ARG151
A	ILE154
A	TRP158
A	CLR1202

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CLR A 1202

Chain	Residue
A	ILE55
A	ALA85
A	CLR1201

---

site_id	AC3
Number of Residues	6
Details	binding site for residue JTZ A 1203

Chain	Residue
A	TRP109
A	ASP113
A	VAL114
A	SER203
A	PHE290
A	ASN312

---

site_id	AC4
Number of Residues	7
Details	binding site for residue M3J A 1204

Chain	Residue
A	LEU45
A	GLU122
A	CYS125
A	VAL129
A	VAL206
A	VAL210
A	PRO211

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI

Chain	Residue	Details
A	ALA119-ILE135

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	32
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"24056936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18547522","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3D4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17952055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17962520","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8521811","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"27481942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"17962520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18547522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2540197","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27481942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---