6OA3
Structure of human PARG complexed with JA2131
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Poly(ADP-ribose) glycohydrolase | polymer | 533 | 61223.6 | 1 | UniProt (Q86W56) Pfam (PF20811) Pfam (PF05028) In PDB | Homo sapiens (Human) | |
2 | A | (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one | non-polymer | 343.5 | 1 | Chemie (M0M) | |||
3 | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 448 - 976 (UniProt: Q86W56)
PDB | External Database | Details |
---|---|---|
Gly 444 | - | expression tag |
Pro 445 | - | expression tag |
His 446 | - | expression tag |
Met 447 | - | expression tag |
Ala 616 | Lys 616 | engineered mutation |
Ala 617 | Gln 617 | engineered mutation |
Ala 618 | Lys 618 | engineered mutation |
Ala 688 | Glu 688 | engineered mutation |
Ala 689 | Lys 689 | engineered mutation |
Ala 690 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 61223.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 343.5 | |
All* | Total formula weight | 61567.1 |