6O9C

Crystal structure of HLA-A3*01 in complex with a mutant beta-catenin peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, A-3 alpha chain	polymer	300	34589.2	1	UniProt (P04439) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (Human)	MHC class I antigen A*3
2	B (B)	Beta-2-microglobulin	polymer	119	13732.5	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	Catenin beta-1	polymer	9	922.1	1	UniProt (P35222)	Homo sapiens (Human)	Beta-catenin
4	D, L (A, B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
5	E, F, G, H, I... (A, B)	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
6	P, Q (B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
7	R, S (A, B)	water	water		18.0	43	Chemie (HOH)

Sequence modifications

A: 1 - 280 (UniProt: P04439)

PDB	External Database	Details
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Gly 281	-	expression tag
Ser 282	-	expression tag
Leu 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
Ile 286	-	expression tag
Leu 287	-	expression tag
Asp 288	-	expression tag
Ala 289	-	expression tag
Gln 290	-	expression tag
Lys 291	-	expression tag
Met 292	-	expression tag
Val 293	-	expression tag
Trp 294	-	expression tag
Asn 295	-	expression tag
His 296	-	expression tag
Arg 297	-	expression tag

C: 1 - 9 (UniProt: P35222)

PDB	External Database	Details
Phe 5	Ser 45	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	49243.8
Non-Polymers*	Number of molecules	14
	Total formula weight	1563.3
All*	Total formula weight	50807.2

*Water molecules are not included.