6O4K
Structure of ALDH7A1 mutant E399Q complexed with NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Alpha-aminoadipic semialdehyde dehydrogenase | polymer | 513 | 55619.4 | 8 | UniProt (P49419) Pfam (PF00171) | Homo sapiens (Human) | Alpha-AASA dehydrogenase,Aldehyde dehydrogenase family 7 member A1,Antiquitin-1,Betaine aldehyde dehydrogenase,Delta1-piperideine-6-carboxylate dehydrogenase,P6c dehydrogenase |
| 2 | I, L, V, W (A, B, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | AA, J, M, O, Q... (H, A, B, C, D...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) | |||
| 4 | BA, K, N, P, R... (H, A, B, C, D...) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 5 | CA, DA, EA, FA, GA... (A, B, C, D, E...) | water | water | 18.0 | 1250 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 511 (UniProt: P49419)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Gln 399 | Glu 427 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 444955.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 5839.3 | |
| All* | Total formula weight | 450794.4 |
