6O4C
Structure of ALDH7A1 mutant W175A complexed with NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Alpha-aminoadipic semialdehyde dehydrogenase | polymer | 513 | 55505.2 | 8 | UniProt (P49419) Pfam (PF00171) | Homo sapiens (Human) | Alpha-AASA dehydrogenase,Aldehyde dehydrogenase family 7 member A1,Antiquitin-1,Betaine aldehyde dehydrogenase,Delta1-piperideine-6-carboxylate dehydrogenase,P6c dehydrogenase, ALDH7A1 |
| 2 | CA, I, JA, N, OA... (E, A, F, B, G...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) | |||
| 3 | DA, J, KA, O, PA... (E, A, F, B, G...) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 8 | Chemie (PGE) | |||
| 4 | FA, K, LA, P, QA... (E, A, F, B, G...) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 8 | Chemie (1PE) | |||
| 5 | AA, BA, GA, HA, L... (D, E, A, G) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 6 | IA, NA, Q (E, F, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 7 | MA, RA, SA, U, V... (F, G, C, D, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 8 | EA (E) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 9 | WA (H) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 10 | AB, BB, CB, DB, EB... (A, B, C, D, E...) | water | water | 18.0 | 3320 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 511 (UniProt: P49419)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 175 | Trp 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 444041.9 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 9506.4 | |
| All* | Total formula weight | 453548.3 |
