6O4C
Structure of ALDH7A1 mutant W175A complexed with NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006081 | biological_process | cellular aldehyde metabolic process |
| A | 0007605 | biological_process | sensory perception of sound |
| A | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| A | 0042426 | biological_process | choline catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006081 | biological_process | cellular aldehyde metabolic process |
| B | 0007605 | biological_process | sensory perception of sound |
| B | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| B | 0042426 | biological_process | choline catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005829 | cellular_component | cytosol |
| C | 0006081 | biological_process | cellular aldehyde metabolic process |
| C | 0007605 | biological_process | sensory perception of sound |
| C | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| C | 0042426 | biological_process | choline catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005829 | cellular_component | cytosol |
| D | 0006081 | biological_process | cellular aldehyde metabolic process |
| D | 0007605 | biological_process | sensory perception of sound |
| D | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| D | 0042426 | biological_process | choline catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0070062 | cellular_component | extracellular exosome |
| E | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| E | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005759 | cellular_component | mitochondrial matrix |
| E | 0005829 | cellular_component | cytosol |
| E | 0006081 | biological_process | cellular aldehyde metabolic process |
| E | 0007605 | biological_process | sensory perception of sound |
| E | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| E | 0042426 | biological_process | choline catabolic process |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0070062 | cellular_component | extracellular exosome |
| F | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| F | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005759 | cellular_component | mitochondrial matrix |
| F | 0005829 | cellular_component | cytosol |
| F | 0006081 | biological_process | cellular aldehyde metabolic process |
| F | 0007605 | biological_process | sensory perception of sound |
| F | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| F | 0042426 | biological_process | choline catabolic process |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0070062 | cellular_component | extracellular exosome |
| G | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| G | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005759 | cellular_component | mitochondrial matrix |
| G | 0005829 | cellular_component | cytosol |
| G | 0006081 | biological_process | cellular aldehyde metabolic process |
| G | 0007605 | biological_process | sensory perception of sound |
| G | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| G | 0042426 | biological_process | choline catabolic process |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0070062 | cellular_component | extracellular exosome |
| H | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| H | 0004043 | molecular_function | L-aminoadipate-semialdehyde dehydrogenase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005759 | cellular_component | mitochondrial matrix |
| H | 0005829 | cellular_component | cytosol |
| H | 0006081 | biological_process | cellular aldehyde metabolic process |
| H | 0007605 | biological_process | sensory perception of sound |
| H | 0008802 | molecular_function | betaine-aldehyde dehydrogenase (NAD+) activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0019285 | biological_process | glycine betaine biosynthetic process from choline |
| H | 0042426 | biological_process | choline catabolic process |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue NAD A 601 |
| Chain | Residue |
| A | ILE163 |
| A | ALA227 |
| A | GLY230 |
| A | THR231 |
| A | PHE244 |
| A | THR245 |
| A | GLY246 |
| A | SER247 |
| A | VAL250 |
| A | GLU268 |
| A | LEU269 |
| A | THR164 |
| A | GLY270 |
| A | CYS302 |
| A | GLU399 |
| A | PHE401 |
| A | PHE468 |
| A | HOH706 |
| A | HOH739 |
| A | HOH756 |
| A | HOH795 |
| A | HOH915 |
| A | ALA165 |
| A | HOH925 |
| A | HOH973 |
| A | HOH994 |
| A | HOH1021 |
| A | PHE166 |
| A | ASN167 |
| A | LYS190 |
| A | GLY191 |
| A | ALA192 |
| A | PRO193 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PGE A 602 |
| Chain | Residue |
| A | GLU121 |
| A | PHE468 |
| A | GLU479 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE A 603 |
| Chain | Residue |
| A | ARG68 |
| A | TRP71 |
| A | ASN240 |
| A | HOH721 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 604 |
| Chain | Residue |
| A | PHE510 |
| A | GLN511 |
| B | VAL287 |
| B | ARG321 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 605 |
| Chain | Residue |
| A | ARG321 |
| B | GLN511 |
| site_id | AC6 |
| Number of Residues | 34 |
| Details | binding site for residue NAD B 601 |
| Chain | Residue |
| B | ILE163 |
| B | THR164 |
| B | ALA165 |
| B | PHE166 |
| B | ASN167 |
| B | LYS190 |
| B | GLY191 |
| B | ALA192 |
| B | PRO193 |
| B | ALA227 |
| B | GLY230 |
| B | THR231 |
| B | PHE244 |
| B | THR245 |
| B | GLY246 |
| B | SER247 |
| B | VAL250 |
| B | VAL254 |
| B | GLU268 |
| B | LEU269 |
| B | GLY270 |
| B | CYS302 |
| B | GLU399 |
| B | PHE401 |
| B | PHE468 |
| B | MG604 |
| B | HOH712 |
| B | HOH716 |
| B | HOH830 |
| B | HOH839 |
| B | HOH955 |
| B | HOH966 |
| B | HOH972 |
| B | HOH993 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue PGE B 602 |
| Chain | Residue |
| B | GLU121 |
| B | ILE464 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE B 603 |
| Chain | Residue |
| B | ARG68 |
| B | TRP71 |
| B | GLU237 |
| B | ASN240 |
| B | HOH780 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 604 |
| Chain | Residue |
| B | NAD601 |
| B | HOH966 |
| B | HOH972 |
| B | HOH993 |
| B | HOH1004 |
| site_id | AD1 |
| Number of Residues | 33 |
| Details | binding site for residue NAD C 601 |
| Chain | Residue |
| C | ALA192 |
| C | PRO193 |
| C | ALA227 |
| C | GLY230 |
| C | THR231 |
| C | PHE244 |
| C | THR245 |
| C | GLY246 |
| C | SER247 |
| C | VAL250 |
| C | VAL254 |
| C | GLU268 |
| C | LEU269 |
| C | GLY270 |
| C | CYS302 |
| C | GLU399 |
| C | PHE401 |
| C | PHE468 |
| C | HOH713 |
| C | HOH722 |
| C | HOH782 |
| C | HOH805 |
| C | HOH898 |
| C | HOH979 |
| C | HOH999 |
| C | HOH1016 |
| C | ILE163 |
| C | THR164 |
| C | ALA165 |
| C | PHE166 |
| C | ASN167 |
| C | LYS190 |
| C | GLY191 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PGE C 602 |
| Chain | Residue |
| C | GLU121 |
| C | GLU479 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE C 603 |
| Chain | Residue |
| C | ARG68 |
| C | TRP71 |
| C | GLU237 |
| C | ARG238 |
| C | ASN240 |
| C | HOH708 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 604 |
| Chain | Residue |
| C | TRP13 |
| C | SER102 |
| C | HOH959 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 605 |
| Chain | Residue |
| C | TYR326 |
| C | ILE329 |
| C | TYR369 |
| C | PRO383 |
| site_id | AD6 |
| Number of Residues | 30 |
| Details | binding site for residue NAD D 601 |
| Chain | Residue |
| D | ILE163 |
| D | THR164 |
| D | ALA165 |
| D | PHE166 |
| D | ASN167 |
| D | LYS190 |
| D | GLY191 |
| D | ALA192 |
| D | PRO193 |
| D | ALA227 |
| D | GLY230 |
| D | THR231 |
| D | PHE244 |
| D | THR245 |
| D | GLY246 |
| D | SER247 |
| D | VAL250 |
| D | VAL254 |
| D | GLU268 |
| D | LEU269 |
| D | GLY270 |
| D | CYS302 |
| D | GLU399 |
| D | PHE401 |
| D | PHE468 |
| D | HOH706 |
| D | HOH737 |
| D | HOH755 |
| D | HOH763 |
| D | HOH1004 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue PGE D 602 |
| Chain | Residue |
| D | GLU121 |
| D | GLU479 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE D 603 |
| Chain | Residue |
| D | ARG68 |
| D | TRP71 |
| D | VAL157 |
| D | GLU237 |
| D | ASN240 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 604 |
| Chain | Residue |
| B | TYR498 |
| D | ARG441 |
| D | HOH910 |
| D | HOH914 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 605 |
| Chain | Residue |
| C | GLN511 |
| D | ARG321 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 606 |
| Chain | Residue |
| C | VAL287 |
| C | ARG321 |
| C | HOH783 |
| D | GLN511 |
| site_id | AE3 |
| Number of Residues | 34 |
| Details | binding site for residue NAD E 601 |
| Chain | Residue |
| E | ILE163 |
| E | THR164 |
| E | ALA165 |
| E | PHE166 |
| E | ASN167 |
| E | LYS190 |
| E | GLY191 |
| E | ALA192 |
| E | PRO193 |
| E | ALA227 |
| E | GLY230 |
| E | THR231 |
| E | PHE244 |
| E | THR245 |
| E | GLY246 |
| E | SER247 |
| E | VAL250 |
| E | GLU268 |
| E | LEU269 |
| E | GLY270 |
| E | CYS302 |
| E | GLU399 |
| E | PHE401 |
| E | PHE468 |
| E | MG607 |
| E | HOH720 |
| E | HOH811 |
| E | HOH842 |
| E | HOH906 |
| E | HOH927 |
| E | HOH936 |
| E | HOH965 |
| E | HOH1022 |
| E | HOH1034 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue PGE E 602 |
| Chain | Residue |
| E | GLU121 |
| E | PHE468 |
| E | GLU479 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue PEG E 603 |
| Chain | Residue |
| E | TYR326 |
| E | ILE329 |
| E | TYR369 |
| E | PRO383 |
| E | HOH748 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue 1PE E 604 |
| Chain | Residue |
| E | ARG68 |
| E | GLU69 |
| E | TRP71 |
| E | GLU237 |
| E | ASN240 |
| E | HOH724 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue CL E 605 |
| Chain | Residue |
| E | GLN511 |
| F | VAL287 |
| F | ARG321 |
| F | HOH785 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue CL E 606 |
| Chain | Residue |
| E | VAL287 |
| E | ARG321 |
| F | PHE510 |
| F | GLN511 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 607 |
| Chain | Residue |
| E | NAD601 |
| E | HOH906 |
| E | HOH1022 |
| site_id | AF1 |
| Number of Residues | 32 |
| Details | binding site for residue NAD F 601 |
| Chain | Residue |
| F | ILE163 |
| F | THR164 |
| F | ALA165 |
| F | PHE166 |
| F | ASN167 |
| F | LYS190 |
| F | GLY191 |
| F | ALA192 |
| F | PRO193 |
| F | ALA227 |
| F | GLY230 |
| F | THR231 |
| F | PHE244 |
| F | THR245 |
| F | GLY246 |
| F | SER247 |
| F | VAL250 |
| F | GLU268 |
| F | LEU269 |
| F | GLY270 |
| F | CYS302 |
| F | GLU399 |
| F | PHE401 |
| F | PHE468 |
| F | MG605 |
| F | HOH712 |
| F | HOH714 |
| F | HOH830 |
| F | HOH837 |
| F | HOH937 |
| F | HOH983 |
| F | HOH1007 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue PGE F 602 |
| Chain | Residue |
| F | GLU121 |
| F | ILE464 |
| F | PHE468 |
| F | GLU479 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue 1PE F 603 |
| Chain | Residue |
| F | ARG68 |
| F | TRP71 |
| F | GLU237 |
| F | ARG238 |
| F | ASN240 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 604 |
| Chain | Residue |
| F | TYR128 |
| F | LEU132 |
| F | SER482 |
| F | HOH745 |
| F | HOH977 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 605 |
| Chain | Residue |
| F | NAD601 |
| F | HOH937 |
| F | HOH983 |
| F | HOH1007 |
| site_id | AF6 |
| Number of Residues | 30 |
| Details | binding site for residue NAD G 601 |
| Chain | Residue |
| G | ILE163 |
| G | THR164 |
| G | ALA165 |
| G | PHE166 |
| G | ASN167 |
| G | LYS190 |
| G | GLY191 |
| G | ALA192 |
| G | PRO193 |
| G | ALA227 |
| G | GLY230 |
| G | THR231 |
| G | PHE244 |
| G | THR245 |
| G | GLY246 |
| G | SER247 |
| G | VAL250 |
| G | GLU268 |
| G | LEU269 |
| G | GLY270 |
| G | CYS302 |
| G | GLU399 |
| G | PHE401 |
| G | PHE468 |
| G | HOH703 |
| G | HOH734 |
| G | HOH749 |
| G | HOH866 |
| G | HOH954 |
| G | HOH1011 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue PGE G 602 |
| Chain | Residue |
| G | CYS302 |
| G | PHE468 |
| G | GLU479 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue 1PE G 603 |
| Chain | Residue |
| G | ARG68 |
| G | GLU69 |
| G | TRP71 |
| G | GLU237 |
| G | ASN240 |
| G | HOH893 |
| G | HOH998 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO G 604 |
| Chain | Residue |
| G | TRP13 |
| G | SER102 |
| G | HOH752 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 605 |
| Chain | Residue |
| G | TYR326 |
| G | ILE329 |
| G | VAL331 |
| G | TYR369 |
| G | PRO383 |
| G | HOH993 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue CL G 606 |
| Chain | Residue |
| G | GLN511 |
| H | VAL287 |
| H | ARG321 |
| H | HOH818 |
| site_id | AG3 |
| Number of Residues | 3 |
| Details | binding site for residue CL G 607 |
| Chain | Residue |
| G | ARG321 |
| G | HOH775 |
| H | GLN511 |
| site_id | AG4 |
| Number of Residues | 29 |
| Details | binding site for residue NAD H 601 |
| Chain | Residue |
| H | ILE163 |
| H | THR164 |
| H | ALA165 |
| H | PHE166 |
| H | ASN167 |
| H | LYS190 |
| H | GLY191 |
| H | ALA192 |
| H | PRO193 |
| H | ALA227 |
| H | GLY230 |
| H | THR231 |
| H | PHE244 |
| H | THR245 |
| H | GLY246 |
| H | SER247 |
| H | VAL250 |
| H | GLU268 |
| H | LEU269 |
| H | GLY270 |
| H | CYS302 |
| H | GLU399 |
| H | PHE401 |
| H | PHE468 |
| H | HOH705 |
| H | HOH721 |
| H | HOH758 |
| H | HOH810 |
| H | HOH892 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue PG4 H 602 |
| Chain | Residue |
| H | GLU121 |
| H | THR303 |
| H | SER460 |
| H | PHE468 |
| H | GLU479 |
| site_id | AG6 |
| Number of Residues | 9 |
| Details | binding site for residue PGE H 603 |
| Chain | Residue |
| B | GLY29 |
| B | SER30 |
| B | LYS66 |
| H | TYR326 |
| H | ILE329 |
| H | VAL331 |
| H | TYR369 |
| H | HOH716 |
| H | HOH923 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE H 604 |
| Chain | Residue |
| H | ARG68 |
| H | TRP71 |
| H | GLU237 |
| H | ASN240 |
| site_id | AG8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 605 |
| Chain | Residue |
| H | TRP13 |
| H | SER102 |
| H | HOH959 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA |
| Chain | Residue | Details |
| A | LEU267-ALA274 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007 |
| Chain | Residue | Details |
| A | GLU268 | |
| B | GLU268 | |
| C | GLU268 | |
| D | GLU268 | |
| E | GLU268 | |
| F | GLU268 | |
| G | GLU268 | |
| H | GLU268 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:26260980 |
| Chain | Residue | Details |
| A | CYS302 | |
| B | CYS302 | |
| C | CYS302 | |
| D | CYS302 | |
| E | CYS302 | |
| F | CYS302 | |
| G | CYS302 | |
| H | CYS302 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:26260980, ECO:0007744|PDB:2J6L, ECO:0007744|PDB:4X0T, ECO:0007744|PDB:4ZUK, ECO:0007744|PDB:4ZVY |
| Chain | Residue | Details |
| A | THR164 | |
| C | LYS190 | |
| C | GLY230 | |
| C | GLY246 | |
| D | THR164 | |
| D | LYS190 | |
| D | GLY230 | |
| D | GLY246 | |
| E | THR164 | |
| E | LYS190 | |
| E | GLY230 | |
| A | LYS190 | |
| E | GLY246 | |
| F | THR164 | |
| F | LYS190 | |
| F | GLY230 | |
| F | GLY246 | |
| G | THR164 | |
| G | LYS190 | |
| G | GLY230 | |
| G | GLY246 | |
| H | THR164 | |
| A | GLY230 | |
| H | LYS190 | |
| H | GLY230 | |
| H | GLY246 | |
| A | GLY246 | |
| B | THR164 | |
| B | LYS190 | |
| B | GLY230 | |
| B | GLY246 | |
| C | THR164 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20207735, ECO:0000269|PubMed:26260980, ECO:0007744|PDB:2J6L, ECO:0007744|PDB:4X0T |
| Chain | Residue | Details |
| A | GLU268 | |
| E | GLU399 | |
| F | GLU268 | |
| F | GLU399 | |
| G | GLU268 | |
| G | GLU399 | |
| H | GLU268 | |
| H | GLU399 | |
| A | GLU399 | |
| B | GLU268 | |
| B | GLU399 | |
| C | GLU268 | |
| C | GLU399 | |
| D | GLU268 | |
| D | GLU399 | |
| E | GLU268 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4ZUL |
| Chain | Residue | Details |
| A | THR303 | |
| D | THR303 | |
| D | GLY461 | |
| D | ALA462 | |
| E | THR303 | |
| E | GLY461 | |
| E | ALA462 | |
| F | THR303 | |
| F | GLY461 | |
| F | ALA462 | |
| G | THR303 | |
| A | GLY461 | |
| G | GLY461 | |
| G | ALA462 | |
| H | THR303 | |
| H | GLY461 | |
| H | ALA462 | |
| A | ALA462 | |
| B | THR303 | |
| B | GLY461 | |
| B | ALA462 | |
| C | THR303 | |
| C | GLY461 | |
| C | ALA462 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN167 | |
| B | ASN167 | |
| C | ASN167 | |
| D | ASN167 | |
| E | ASN167 | |
| F | ASN167 | |
| G | ASN167 | |
| H | ASN167 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBF1 |
| Chain | Residue | Details |
| A | LYS66 | |
| B | LYS66 | |
| C | LYS66 | |
| D | LYS66 | |
| E | LYS66 | |
| F | LYS66 | |
| G | LYS66 | |
| H | LYS66 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBF1 |
| Chain | Residue | Details |
| A | LYS434 | |
| E | LYS472 | |
| F | LYS434 | |
| F | LYS472 | |
| G | LYS434 | |
| G | LYS472 | |
| H | LYS434 | |
| H | LYS472 | |
| A | LYS472 | |
| B | LYS434 | |
| B | LYS472 | |
| C | LYS434 | |
| C | LYS472 | |
| D | LYS434 | |
| D | LYS472 | |
| E | LYS434 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DBF1 |
| Chain | Residue | Details |
| A | LYS509 | |
| B | LYS509 | |
| C | LYS509 | |
| D | LYS509 | |
| E | LYS509 | |
| F | LYS509 | |
| G | LYS509 | |
| H | LYS509 |
