6O20

Cryo-EM structure of TRPV5 with calmodulin bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, B, C, D	Transient receptor potential cation channel subfamily V member 5	polymer	730	82899.7	5	UniProt (Q9XSM3) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) In PDB	Oryctolagus cuniculus (Rabbit)	TrpV5,Epithelial calcium channel 1,ECaC1,Osm-9-like TRP channel 3,OTRPC3
2	F	Calmodulin	polymer	169	19023.9	1	UniProt (P62157) Pfam (PF13499) In PDB	Bos taurus (Bovine)	CaM
3	F	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)

Sequence modifications

F: 0 - 148 (UniProt: P62157)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	433522.2
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	433682.5

*Water molecules are not included.