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6O1S

Structure of human plasma kallikrein protease domain with inhibitor

Replaces:  5TZ9
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(E)
Plasma kallikreinpolymer26329427.31UniProt (P03952)
Pfam (PF00089)
Homo sapiens (Human)Fletcher factor,Kininogenin,Plasma prekallikrein,PKK
2B
(E)
PHOSPHATE IONnon-polymer95.01Chemie (PO4)
3C
(E)
1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
4D
(E)
N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]-1-({4-[(1H-pyrazol-1-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamidenon-polymer415.51Chemie (7SD)
5E
(E)
waterwater18.0208Chemie (HOH)
Sequence modifications
E: 376 - 638 (UniProt: P03952)
PDBExternal DatabaseDetails
Glu 396Asn 396engineered mutation
Glu 453Asn 453engineered mutation
Glu 494Asn 494engineered mutation
Ser 503Cys 503engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight29427.3
Non-Polymers*Number of molecules3
Total formula weight572.5
All*Total formula weight29999.8
*Water molecules are not included.

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PDB entries from 2026-01-14

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