6O0P
crystal structure of BCL-2 G101A mutation with venetoclax
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2 | polymer | 166 | 19371.6 | 1 | UniProt (P10415) UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
| 2 | B (A) | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide | non-polymer | 868.4 | 1 | Chemie (LBM) | |||
| 3 | C, D, E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 4 | F (A) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 1 - 34 (UniProt: P10415)
A: 35 - 91 (UniProt: Q07817)
A: 92 - 207 (UniProt: P10415)
A: 35 - 91 (UniProt: Q07817)
A: 92 - 207 (UniProt: P10415)
| PDB | External Database | Details |
|---|---|---|
| Ala 101 | Gly 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19371.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1186.8 | |
| All* | Total formula weight | 20558.4 |
