6O0P

crystal structure of BCL-2 G101A mutation with venetoclax

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue LBM A 301

Chain	Residue
A	ARG12
A	ASN143
A	TRP144
A	GLY145
A	VAL148
A	ALA149
A	GLU152
A	PHE153
A	PHE198
A	TYR202
A	HOH404
A	ALA100
A	HOH408
A	HOH427
A	ASP103
A	PHE104
A	ARG107
A	TYR108
A	ASP111
A	MET115
A	LEU137

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PEG A 302

Chain	Residue
A	ARG12
A	TYR108
A	ASP171
A	PEG303

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PEG A 303

Chain	Residue
A	ARG12
A	TYR108
A	PEG302

---

site_id	AC4
Number of Residues	1
Details	binding site for residue PEG A 304

Chain	Residue
A	ARG107

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG

Chain	Residue	Details
A	LEU137-GLY155

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV

Chain	Residue	Details
A	TRP188-VAL199

---

site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW

Chain	Residue	Details
A	ASP10-TRP30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"BH4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00025","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	19
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---