6NVK
FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 4 | polymer | 300 | 33867.2 | 1 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (Human) | FGFR-4 |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | N-[(3S,4S)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide | non-polymer | 505.4 | 1 | Chemie (XL9) | |||
| 4 | F (A) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 450 - 742 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Met 449 | - | expression tag |
| - | Pro 570 | deletion |
| - | Asp 571 | deletion |
| - | Leu 572 | deletion |
| - | Ser 573 | deletion |
| - | Pro 574 | deletion |
| - | Asp 575 | deletion |
| - | Gly 576 | deletion |
| - | Pro 577 | deletion |
| - | Arg 578 | deletion |
| His 743 | - | expression tag |
| His 744 | - | expression tag |
| His 745 | - | expression tag |
| His 746 | - | expression tag |
| His 747 | - | expression tag |
| His 748 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33867.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 793.6 | |
| All* | Total formula weight | 34660.8 |
