6NVK

FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 801

Chain	Residue
A	ARG563
A	ARG566
A	GLY678
A	SER679

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 802

Chain	Residue
A	LYS555
A	ARG565
A	ASN615

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 803

Chain	Residue
A	HIS704
A	ARG701
A	PRO703

---

site_id	AC4
Number of Residues	14
Details	binding site for residue XL9 A 804

Chain	Residue
A	LEU473
A	VAL481
A	ARG483
A	LYS503
A	GLU520
A	VAL550
A	GLU551
A	CYS552
A	ALA553
A	ALA554
A	GLY556
A	LEU610
A	ALA620
A	ASP621

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVrAeafgmdparpdqast...VAVK

Chain	Residue	Details
A	LEU473-LYS503

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS599-VAL611

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---