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6NVK

FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 801
ChainResidue
AARG563
AARG566
AGLY678
ASER679

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 802
ChainResidue
ALYS555
AARG565
AASN615

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 803
ChainResidue
AHIS704
AARG701
APRO703

site_idAC4
Number of Residues14
Detailsbinding site for residue XL9 A 804
ChainResidue
ALEU473
AVAL481
AARG483
ALYS503
AGLU520
AVAL550
AGLU551
ACYS552
AALA553
AALA554
AGLY556
ALEU610
AALA620
AASP621

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues31
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVrAeafgmdparpdqast...VAVK
ChainResidueDetails
ALEU473-LYS503

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
ChainResidueDetails
ACYS599-VAL611

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
ATHR612

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU473
ALYS503

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
AGLY573

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:18670643
ChainResidueDetails
ALEU642
APRO643

224572

PDB entries from 2024-09-04

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