6NT9

Cryo-EM structure of the complex between human TBK1 and chicken STING

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Serine/threonine-protein kinase TBK1	polymer	742	85316.7	2	UniProt (Q9UHD2) Pfam (PF00069) Pfam (PF18396) Pfam (PF18394)	Homo sapiens (Human)	NF-kappa-B-activating kinase,T2K,TANK-binding kinase 1
2	B, D (C, D)	Stimulator of interferon genes protein	polymer	392	44207.1	2	UniProt (A0A1D5P7Q9) Pfam (PF15009) UniProt (by SIFTS) (E1C7U0)	Gallus gallus (Chicken)

Sequence modifications

A, B: 1 - 729 (UniProt: Q9UHD2)

PDB	External Database	Details
Asn 135	Asp 135	engineered mutation
Gly 730	-	expression tag
Ile 731	-	expression tag
His 732	-	expression tag
Arg 733	-	expression tag
Pro 734	-	expression tag
Asp 735	-	expression tag
Tyr 736	-	expression tag
Lys 737	-	expression tag
Asp 738	-	expression tag
Asp 739	-	expression tag
Asp 740	-	expression tag
Asp 741	-	expression tag
Lys 742	-	expression tag

C, D: 1 - 379 (UniProt: A0A1D5P7Q9)

PDB	External Database	Details
Gly 380	-	expression tag
Ile 381	-	expression tag
His 382	-	expression tag
Arg 383	-	expression tag
Pro 384	-	expression tag
Asp 385	-	expression tag
Tyr 386	-	expression tag
Lys 387	-	expression tag
Asp 388	-	expression tag
Asp 389	-	expression tag
Asp 390	-	expression tag
Asp 391	-	expression tag
Lys 392	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	259047.5
All*	Total formula weight	259047.5

*Water molecules are not included.