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6NT9

Cryo-EM structure of the complex between human TBK1 and chicken STING

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002218biological_processactivation of innate immune response
A0002376biological_processimmune system process
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003676molecular_functionnucleic acid binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0007249biological_processcanonical NF-kappaB signal transduction
A0009615biological_processresponse to virus
A0009967biological_processpositive regulation of signal transduction
A0010468biological_processregulation of gene expression
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016239biological_processpositive regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019903molecular_functionprotein phosphatase binding
A0032479biological_processregulation of type I interferon production
A0032481biological_processpositive regulation of type I interferon production
A0032727biological_processpositive regulation of interferon-alpha production
A0032728biological_processpositive regulation of interferon-beta production
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034142biological_processtoll-like receptor 4 signaling pathway
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043231cellular_componentintracellular membrane-bounded organelle
A0044565biological_processdendritic cell proliferation
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050830biological_processdefense response to Gram-positive bacterium
A0051219molecular_functionphosphoprotein binding
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0106310molecular_functionprotein serine kinase activity
A0140374biological_processantiviral innate immune response
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904417biological_processpositive regulation of xenophagy
B0000166molecular_functionnucleotide binding
B0002218biological_processactivation of innate immune response
B0002376biological_processimmune system process
B0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
B0003676molecular_functionnucleic acid binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006468biological_processprotein phosphorylation
B0006954biological_processinflammatory response
B0007249biological_processcanonical NF-kappaB signal transduction
B0009615biological_processresponse to virus
B0009967biological_processpositive regulation of signal transduction
B0010468biological_processregulation of gene expression
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0016239biological_processpositive regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019903molecular_functionprotein phosphatase binding
B0032479biological_processregulation of type I interferon production
B0032481biological_processpositive regulation of type I interferon production
B0032727biological_processpositive regulation of interferon-alpha production
B0032728biological_processpositive regulation of interferon-beta production
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034142biological_processtoll-like receptor 4 signaling pathway
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043231cellular_componentintracellular membrane-bounded organelle
B0044565biological_processdendritic cell proliferation
B0045087biological_processinnate immune response
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050830biological_processdefense response to Gram-positive bacterium
B0051219molecular_functionphosphoprotein binding
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0106310molecular_functionprotein serine kinase activity
B0140374biological_processantiviral innate immune response
B0140896biological_processcGAS/STING signaling pathway
B1902554cellular_componentserine/threonine protein kinase complex
B1904262biological_processnegative regulation of TORC1 signaling
B1904263biological_processpositive regulation of TORC1 signaling
B1904417biological_processpositive regulation of xenophagy
C0000045biological_processautophagosome assembly
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000421cellular_componentautophagosome membrane
C0002218biological_processactivation of innate immune response
C0002376biological_processimmune system process
C0005737cellular_componentcytoplasm
C0005776cellular_componentautophagosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0006811biological_processmonoatomic ion transport
C0006914biological_processautophagy
C0015252molecular_functionproton channel activity
C0016020cellular_componentmembrane
C0016239biological_processpositive regulation of macroautophagy
C0031410cellular_componentcytoplasmic vesicle
C0032481biological_processpositive regulation of type I interferon production
C0032728biological_processpositive regulation of interferon-beta production
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035438molecular_functioncyclic-di-GMP binding
C0042803molecular_functionprotein homodimerization activity
C0045087biological_processinnate immune response
C0048471cellular_componentperinuclear region of cytoplasm
C0051259biological_processprotein complex oligomerization
C0051607biological_processdefense response to virus
C0061507molecular_function2',3'-cyclic GMP-AMP binding
C0061709biological_processreticulophagy
C0140896biological_processcGAS/STING signaling pathway
C1902600biological_processproton transmembrane transport
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000421cellular_componentautophagosome membrane
D0002218biological_processactivation of innate immune response
D0002376biological_processimmune system process
D0005737cellular_componentcytoplasm
D0005776cellular_componentautophagosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0006811biological_processmonoatomic ion transport
D0006914biological_processautophagy
D0015252molecular_functionproton channel activity
D0016020cellular_componentmembrane
D0016239biological_processpositive regulation of macroautophagy
D0031410cellular_componentcytoplasmic vesicle
D0032481biological_processpositive regulation of type I interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035438molecular_functioncyclic-di-GMP binding
D0042803molecular_functionprotein homodimerization activity
D0045087biological_processinnate immune response
D0048471cellular_componentperinuclear region of cytoplasm
D0051259biological_processprotein complex oligomerization
D0051607biological_processdefense response to virus
D0061507molecular_function2',3'-cyclic GMP-AMP binding
D0061709biological_processreticulophagy
D0140896biological_processcGAS/STING signaling pathway
D1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........FAIK
ChainResidueDetails
ALEU15-LYS38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues564
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30842659
ChainResidueDetails
CMET1-ARG23
CILE76-PRO97
CGLY140-PRO379
DMET1-ARG23
DILE76-PRO97
DGLY140-PRO379

site_idSWS_FT_FI2
Number of Residues32
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30842659
ChainResidueDetails
CALA24-PHE40
DALA24-PHE40

site_idSWS_FT_FI3
Number of Residues36
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:30842659
ChainResidueDetails
CLEU41-ILE50
CLEU112-SER121
DLEU41-ILE50
DLEU112-SER121

site_idSWS_FT_FI4
Number of Residues48
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30842659
ChainResidueDetails
CARG51-GLU75
DARG51-GLU75

site_idSWS_FT_FI5
Number of Residues26
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30842659
ChainResidueDetails
CARG98-TYR111
DARG98-TYR111

site_idSWS_FT_FI6
Number of Residues34
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30842659
ChainResidueDetails
CPRO122-LEU139
DPRO122-LEU139
BLYS30
BLYS401

site_idSWS_FT_FI7
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q86WV6
ChainResidueDetails
CSER167
CTYR172
CARG243
CSER268
DSER167
DTYR172
DARG243
DSER268

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000305|PubMed:30842653
ChainResidueDetails
CSER366
DSER366

218853

PDB entries from 2024-04-24

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