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6NN5

The structure of human liver pyruvate kinase, hLPYK-W527H

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Pyruvate kinase PKLRpolymer54358516.14UniProt (P30613)
Pfam (PF00224)
Pfam (PF02887)
Homo sapiens (Human)Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2E, F, G, H, L...
(A, B, C, D)
GLYCEROLnon-polymer92.112Chemie (GOL)
3I, J, K, N, O...
(A, B, C, D)
1,2-ETHANEDIOLnon-polymer62.110Chemie (EDO)
4AA, BA, CA, DA
(A, B, C, D)
waterwater18.0196Chemie (HOH)
Sequence modifications
A, B, C, D: 3 - 543 (UniProt: P30613)
PDBExternal DatabaseDetails
Met 1-expression tag
Glu 2-expression tag
His 527Trp 558engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight234064.4
Non-Polymers*Number of molecules22
Total formula weight1725.8
All*Total formula weight235790.2
*Water molecules are not included.

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PDB entries from 2024-10-30

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