6NN5
The structure of human liver pyruvate kinase, hLPYK-W527H
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKLR | polymer | 543 | 58516.1 | 4 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (Human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
2 | E, F, G, H, L... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 12 | Chemie (GOL) | |||
3 | I, J, K, N, O... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
4 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 196 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 543 (UniProt: P30613)
PDB | External Database | Details |
---|---|---|
Met 1 | - | expression tag |
Glu 2 | - | expression tag |
His 527 | Trp 558 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 234064.4 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 1725.8 | |
All* | Total formula weight | 235790.2 |