6NMT
Non-Blocking Fab 3 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fab 3 anti-SIRP-alpha antibody Variable Light Chain | polymer | 209 | 22416.7 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | Fab 3 anti-SIRP-alpha antibody Variable Heavy Chain | polymer | 228 | 23881.7 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | Tyrosine-protein phosphatase non-receptor type substrate 1 | polymer | 127 | 14031.8 | 1 | UniProt (P78324) Pfam (PF07686) | Homo sapiens (Human) | SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Sirp-alpha-1,Signal-regulatory protein alpha-2,Sirp-alpha-2,Signal-regulatory protein alpha-3,Sirp-alpha-3,p84 |
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 655 | Chemie (HOH) |
Sequence modifications
C: 1 - 119 (UniProt: P78324)
| PDB | External Database | Details |
|---|---|---|
| Ala 80 | Asn 110 | conflict |
| Thr 120 | - | expression tag |
| Arg 121 | - | expression tag |
| His 122 | - | expression tag |
| His 123 | - | expression tag |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
| His 126 | - | expression tag |
| His 127 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60330.1 | |
| All* | Total formula weight | 60330.1 |
