6NM4
Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase PRDM9 | polymer | 191 | 21802.4 | 2 | UniProt (Q9NQV7) Pfam (PF21549) | Homo sapiens (Human) | PR domain zinc finger protein 9, PR domain-containing protein 9 |
| 2 | C, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, I (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (58766358) PubChem (73897310) PubChem (9865603) PubChem (87224684) PubChem (12312798) PubChem (131697735) PubChem (145712080) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 4 | E, J (A, B) | 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane | non-polymer | 464.6 | 2 | Chemie (KS7) PubChem (137331596) | |||
| 5 | F, G, K (A, B) | UNKNOWN ATOM OR ION | non-polymer | 3 | Chemie (UNX) | ||||
| 6 | L, M (A, B) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43604.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1856.8 | |
| All* | Total formula weight | 45461.5 |
