6NM4
Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase PRDM9 | polymer | 191 | 21802.4 | 2 | UniProt (Q9NQV7) Pfam (PF21549) | Homo sapiens (Human) | PR domain zinc finger protein 9, PR domain-containing protein 9 |
| 2 | C, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, I (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | E, J (A, B) | 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane | non-polymer | 464.6 | 2 | Chemie (KS7) | |||
| 5 | F, G, K (A, B) | UNKNOWN ATOM OR ION | non-polymer | 3 | Chemie (UNX) | ||||
| 6 | L, M (A, B) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43604.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1856.8 | |
| All* | Total formula weight | 45461.5 |
